Early Growth Response Gene Upregulation in Epstein-Barr Virus (EBV)-Associated Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
Early Growth Response Gene Upregulation in Epstein-Barr Virus (EBV)-Associated Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
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EB 病毒 (EBV) 相关肌痛性脑脊髓炎/慢性疲劳综合征 (ME/CFS) 中的早期生长反应基因上调。
DOI：
10.3390/biom10111484
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发表时间：
2020-10-26
期刊：
影响因子：
5.5
通讯作者：
Kerr J
中科院分区：
文献类型：
--
作者：
Kerr J
肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）是一种慢性多系统疾病，表现出多种症状并影响多个系统。心理压力和病毒感染很重要。病毒感染可能会引发发病，心理压力可能会重新激活潜伏的病毒，例如爱泼斯坦-巴尔病毒（EBV）。最近有报道称，部分 ME/CFS 患者血液中 EBV 诱导基因 2 (EBI2) 表达上调。本研究的目的是确定早期生长反应 (EGR) 基因（在 EBV 感染中很重要，并且也被发现在 ME/CFS 患者血液中上调）的表达模式是否与 EBI2 相似。发现 EGR 基因上调与 ME/CFS 中的 EBI2 密切相关，这为支持部分 ME/CFS 患者中正在进行的 EBV 再激活提供了进一步的证据。 EGR1、EGR2 和 EGR3 是细胞立即早期基因反应的一部分，在 EBV 转录、重新激活和 B 淋巴细胞转化中发挥重要作用。 EGR1是免疫功能的调节剂，在血管稳态、心理应激、结缔组织疾病、线粒体功能中发挥重要作用，所有这些都与ME/CFS相关。 EGR2和EGR3是T淋巴细胞的负调节因子，在系统性自身免疫中很重要。
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic multisystem disease exhibiting a variety of symptoms and affecting multiple systems. Psychological stress and virus infection are important. Virus infection may trigger the onset, and psychological stress may reactivate latent viruses, for example, Epstein–Barr virus (EBV). It has recently been reported that EBV induced gene 2 (EBI2) was upregulated in blood in a subset of ME/CFS patients. The purpose of this study was to determine whether the pattern of expression of early growth response (EGR) genes, important in EBV infection and which have also been found to be upregulated in blood of ME/CFS patients, paralleled that of EBI2. EGR gene upregulation was found to be closely associated with that of EBI2 in ME/CFS, providing further evidence in support of ongoing EBV reactivation in a subset of ME/CFS patients. EGR1, EGR2, and EGR3 are part of the cellular immediate early gene response and are important in EBV transcription, reactivation, and B lymphocyte transformation. EGR1 is a regulator of immune function, and is important in vascular homeostasis, psychological stress, connective tissue disease, mitochondrial function, all of which are relevant to ME/CFS. EGR2 and EGR3 are negative regulators of T lymphocytes and are important in systemic autoimmunity.
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影响因子：
5.4
作者：
Conacher, M;Callard, R;Crawford, DH
通讯作者：
Crawford, DH
影响因子：
158.5
作者：
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通讯作者：
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影响因子：
3.9
作者：
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DOI：
10.1073/pnas.0600666103
发表时间：
2006-05-23
影响因子：
11.1
作者：
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通讯作者：
O'Shea, John J.
影响因子：
37.3
作者：
Liu TY;Wu SJ;Huang MH;Lo FY;Tsai MH;Tsai CH;Hsu SM;Lin CW
通讯作者：
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