Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer.
Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer.
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DOI：
10.1155/2018/6319649
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发表时间：
2018
影响因子：
4.1
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Ma J;Xu H;Wang S
肺癌由于诊断晚、预后差，是世界范围内癌症死亡的主要原因。免疫治疗在肺癌的治疗中越来越受到人们的欢迎，前景看好。髓系抑制细胞(MDSCs)是主要的肿瘤抑制因子，靶向MDSCs的治疗策略逐渐出现。在这篇综述中，我们总结了目前已知的MDSCs在肺癌中的作用。鉴于MDSCs在肺癌中的重要性，靶向MDSCs的治疗将有助于控制肺癌的发生和发展。然而，肿瘤的发生、转移和生存是多因素、多机制共同作用的结果，采用不同策略的综合治疗将成为未来肺癌的主要治疗方法。
Lung cancer is the leading cause of cancer death worldwide due to its late diagnosis and poor outcome. Immunotherapy is becoming more and more encouraging and promising in lung cancer therapy. Myeloid-derived suppressor cells (MDSCs) are the main tumor suppressor factors, and the treatment strategy of targeting MDSCs is gradually emerging. In this review, we summarize what is currently known about the role of MDSCs in lung cancer. In view of the emerging importance of MDSCs in lung cancer, the treatment of targeting MDSCs will be useful to the control of the development and progression of lung cancer. However, the occurrence, metastasis, and survival of cancer is the result of multiple factors and multiple mechanisms, so combined treatments using different strategies will become the major therapy method for lung cancer in the future.
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影响因子：
10.1
作者：
Hossain, Fokhrul;Al-Khami, Amir A.;Ochoa, Augusto C.
通讯作者：
Ochoa, Augusto C.
影响因子：
8.8
作者：
Gato-Canas, Maria;Zuazo, Miren;Escors, David
通讯作者：
Escors, David
影响因子：
15.9
作者：
Crane, Courtney A.;Han, Seunggu J.;Parsa, Andrew T.
通讯作者：
Parsa, Andrew T.
影响因子：
5.5
作者：
Chen, Xi;Zhang, Zhengguo;Liu, Guangwei
通讯作者：
Liu, Guangwei
影响因子：
16.6
作者：
Bronte V;Brandau S;Chen SH;Colombo MP;Frey AB;Greten TF;Mandruzzato S;Murray PJ;Ochoa A;Ostrand-Rosenberg S;Rodriguez PC;Sica A;Umansky V;Vonderheide RH;Gabrilovich DI
通讯作者：
Gabrilovich DI