Histology atlas of the developing mouse hepatobiliary system with emphasis on embryonic days 9.5-18.5.
Histology atlas of the developing mouse hepatobiliary system with emphasis on embryonic days 9.5-18.5.
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DOI：
10.1177/0192623310374329
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发表时间：
2010-10
影响因子：
1.5
通讯作者：
Elmore SA
中科院分区：
文献类型：
--
作者：
Crawford LW;Foley JF;Elmore SA
动物模型表型、宫内暴露毒理学研究以及胚胎、胎儿或围产期死亡原因的调查都要求病理学家认识和诊断自发和工程小鼠疾病模型的发育障碍。在哺乳动物中，肝脏是胎儿发育过程中的主要造血部位，具有对维持胎儿和成年生活中的动态平衡至关重要的内分泌和外分泌功能；还具有其他功能，包括排毒、生产和去除葡萄糖、糖原储存、甘油三酯和脂肪酸加工以及血清蛋白质生产。由于它在许多关键功能中的作用，肝脏的大小、形态或功能的改变通常会导致胚胎死亡(S)。许多出版物和网站描述了肝胆发育在特定阶段的个别方面。然而，没有一个单一的来源提供了使用高倍率和高分辨率彩色图像对发育中的小鼠肝脏和胆管系统的H&E染色切片进行详细的组织学评估。本研究提供了9.5-18.5天胚胎肝胆发育的组织学图谱。虽然这项工作的重点是正常的肝胆发育，但肝脏发育中常见的缺陷也被描述为病理学家的参考，他们可能被要求对患有先天性、遗传性或治疗相关肝胆缺陷的小鼠进行表型分析。
Animal model phenotyping, in utero exposure toxiciy studies, and investigation into causes of embryonic, fetal, or perinatal deaths have required pathologists to recognize and diagnose developmental disorders in spontaneous and engineered mouse models of disease. In mammals, the liver is the main site of hematopoiesis during fetal development, has endocrine and exocrine functions important for maintaining homeostasis in fetal and adult life; and performs other functions including waste detoxification, production and removal of glucose, glycogen storage, triglyceride and fatty acid processing, and serum protein production. Due to its role in many critical functions, alterations in the size, morphology, or function(s) of the liver often lead to embryonic lethality. Many publications and websites describe individual aspects of hepatobiliary development at defined stages. However, no single resource provides a detailed histological evaluation of H&E-stained sections of the developing murine liver and biliary systems using high-magnification and high-resolution color images. The work herein provides a histology atlas of hepatobiliary development between embryonic days 9.5-18.5. Although the focus of this work is normal hepatobiliary development, common defects in liver development are also described as a reference for pathologists who may be asked to phenotype mice with congenital, inherited, or treatment-related hepatobiliary defects.
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