Transitions in and out of alcohol use disorders: their associations with conditional changes in quality of life over a 3-year follow-up interval.
Transitions in and out of alcohol use disorders: their associations with conditional changes in quality of life over a 3-year follow-up interval.
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DOI：
10.1093/alcalc/agn094
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发表时间：
2009-01
影响因子：
2.8
通讯作者：
Grant, Bridget F.
中科院分区：
文献类型：
--
作者：
Dawson, Deborah A.;Li, Ting-Kai;Chou, S. Patricia;Grant, Bridget F.
研究美国一般人群样本3年随访期间生活质量（QOL）随酒精使用障碍（AUD）转变的纵向变化。这项分析是基于在第一波全国酒精和相关疾病流行病学调查前一年饮酒的个人，并在第二波（n= 22，245）重新采访。使用多元线性回归模型，估计SF-12 QOL的变化作为DSM-IV AUD转换的函数，控制基线QOL和多种潜在混杂因素。AUD的发作和抵消与精神/心理功能的变化密切相关，在产生依赖的个体中，精神成分汇总（NBMCS）评分显著降低，而在完全和部分缓解依赖的个体中，NBMCS评分显著增加。总体NBMCS及其社会功能，角色情感和心理健康成分的增加对于戒断和非戒断依赖缓解同样重要，但身体疼痛和一般健康状况的改善仅与非戒断缓解相关。滥用的发生与生活质量的变化无关，与滥用的非戒断缓解相关的NBMCS增加是轻微的。只有滥用或没有AUD的个体停止饮酒后生活质量显著下降。这些结果表明预防和治疗AUD对维持和/或改善QOL可能具有重要意义。他们也与病态放弃者假说相一致，并认为虐待与其说是一种精神障碍，不如说是一种适应不良的行为模式。
To investigate longitudinal changes in quality of life (QOL) as a function of transitions in alcohol use disorders (AUD) over a 3-year follow-up of a general U.S. population sample. The analysis is based on individuals who drank alcohol in the year preceding the Wave 1 National Epidemiologic Survey on Alcohol and Related Conditions and were reinterviewed at Wave 2 (n=22,245). Using multiple linear regression models, changes in SF-12 QOL were estimated as a function of DSM-IV AUD transitions, controlling for baseline QOL and multiple potential confounders. Onset and offset of AUD were strongly associated with changes in mental/psychological functioning, with significant decreases in mental component summary (NBMCS) scores among individuals who developed dependence and significant increases among those who achieved full and partial remission from dependence. The increases in overall NBMCS and its social functioning, role emotional and mental health components were equally great for abstinent and nonabstinent remission from dependence, but improvements in bodily pain and general health were associated with nonabstinent remission only. Onset of abuse was unrelated to changes in QOL, and the increase in NBMCS associated with nonabstinent remission from abuse only was slight. Individuals with abuse only or no AUD who stopped drinking had significant declines in QOL. These results suggest the possible importance of preventing and treating AUD for maintaining and/or improving QOL. They are also consistent with the sick quitter hypothesis and suggest that abuse is less a mental disorder than a maladaptive pattern of behavior.
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DOI：
10.15288/jsa.1999.60.790
发表时间：
1999-11-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Canino, G;Bravo, M;Hasin, D
通讯作者：
Hasin, D
DOI：
10.1097/01.mrr.0000127350.25287.08
发表时间：
2004-06-01
影响因子：
1.7
作者：
Bohannon, RW;Maljanian, R;Landes, M
通讯作者：
Landes, M
影响因子：
4.2
作者：
Cottler, LB;Grant, BF;Mager, D
通讯作者：
Mager, D
影响因子：
2.7
作者：
Daeppen, JB;Krieg, MA;Yersin, B
通讯作者：
Yersin, B
影响因子：
4.1
作者：
King, JT;Horowitz, MB;Roberts, MS
通讯作者：
Roberts, MS