Local and global functions of Timeless and Tipin in replication fork protection.
Local and global functions of Timeless and Tipin in replication fork protection.
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DOI：
10.4161/cc.21989
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发表时间：
2012-11-01
期刊：
影响因子：
--
通讯作者：
Noguchi E
中科院分区：
文献类型：
--
作者：
Leman AR;Noguchi E
真核细胞在每个细胞周期过程中几乎绝对忠实地复制其染色体DNA。考虑到DNA复制的条件很少是理想的，这一成就是了不起的。复制机器在染色体上遇到各种障碍，包括受损的模板DNA。此外，由于DNA二级结构和染色体上各种交易所需的DNA结合蛋白，许多染色体区域被认为难以复制。在这些条件下，复制叉停滞或断裂，对基因组的完整性构成严重威胁。在DNA复制过程中，细胞如何对抗这种压力条件？复制叉保护复合体（FPC）可能有助于回答这个问题。最近的研究表明，FPC是复制叉在难以复制的基因组区域顺利通过所必需的，并且在协调复制叉处的多个基因组维护过程中起着关键作用。
The eukaryotic cell replicates its chromosomal DNA with almost absolute fidelity in the course of every cell cycle. This accomplishment is remarkable considering that the conditions for DNA replication are rarely ideal. The replication machinery encounters a variety of obstacles on the chromosome, including damaged template DNA. In addition, a number of chromosome regions are considered to be difficult to replicate owing to DNA secondary structures and DNA binding proteins required for various transactions on the chromosome. Under these conditions, replication forks stall or break, posing grave threats to genomic integrity. How does the cell combat such stressful conditions during DNA replication? The replication fork protection complex (FPC) may help answer this question. Recent studies have demonstrated that the FPC is required for the smooth passage of replication forks at difficult-to-replicate genomic regions and plays a critical role in coordinating multiple genome maintenance processes at the replication fork.
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