Large-scale mapping of branchpoints in human pre-mRNA transcripts in vivo.
Large-scale mapping of branchpoints in human pre-mRNA transcripts in vivo.
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DOI:
10.1038/nsmb.2327
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发表时间:
2012-06-17
影响因子:
16.8
通讯作者:
Fairbrother, William G.
中科院分区:
文献类型:
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作者:
Taggart, Allison J.;DeSimone, Alec M.;Shih, Janice S.;Filloux, Madeleine E.;Fairbrother, William G.
We present the first large-scale identification of lariats—the transient branched introns that are released as a byproduct of pre-mRNA splicing. The locations of the branchpoints in these introns provide insight into the early steps of splicing. From this data set, we have developed a comprehensive model of 3′ splice-site selection, identified new mechanisms of alternative splicing and mapped the distribution of splicing factors around branchpoints.
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影响因子:
14.9
作者:
Ding, Y;Chan, CY;Lawrence, CE
通讯作者:
Lawrence, CE
影响因子:
5.3
作者:
LEGRAIN, P;SERAPHIN, B;ROSBASH, M
通讯作者:
ROSBASH, M
影响因子:
5.3
作者:
Chua, K;Reed, R
通讯作者:
Reed, R
影响因子:
16.8
作者:
通讯作者:
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影响因子:
16.8
作者:
通讯作者:
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