Patterns of recurrence in oral tongue cancer with perineural invasion.
Patterns of recurrence in oral tongue cancer with perineural invasion.
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DOI：
10.1002/hed.25110
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Wong RJ
中科院分区：
文献类型：
--
作者：
Cracchiolo JR;Xu B;Migliacci JC;Katabi N;Pfister DG;Lee NY;Patel SG;Ghossein RA;Wong RJ
虽然神经侵袭(PNI)被认为是口腔舌鳞状细胞癌(OTSCC)的不良预后因素，但失败的模式并不明确。确定接受过初次手术治疗的OTSCC患者。头颈部病理学家对标本进行了复查。计算疾病特异性生存率(DSS)和局部、区域及远处无复发生存率(LRFS、RRFS和DRFS)。分析PNI和PNI特征作为预后的预测因子。PNI患者的DSS降低，但PNI不能预测LRFS或RRFS。PNI患者发生远处复发的可能性更大，如果病灶密度为<1，则发生远处复发的可能性更大(CI6.70-56.14，p<；0.001)。高病灶密度与较差的DRFS相关。
Although perineural invasion (PNI) is recognized as an adverse prognostic factor in oral tongue squamous cell carcinoma (OTSCC), the patterns of failure are poorly defined. Patients with OTSCC who received primary surgical treatment were identified. Specimens were reviewed by head and neck pathologists. Disease specific survival (DSS) and local, regional and distant recurrence free survival (LRFS, RRFS and DRFS) were calculated. PNI and PNI characteristics were analyzed as predictors of outcome. Patients with PNI had a decreased DSS however, PNI was not predictive of LRFS or RRFS. Patients with PNI were more likely to develop a distant recurrence and 19.40 (CI 6.70–56.14, p<0.001) more likely to develop a distant recurrence if foci density was >1. The presence of PNI in OTSCC predicts for worse DSS with distant recurrence as the most common pattern of failure. High foci density is associated with worse DRFS.
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影响因子：
4.8
作者：
Huang, Tsai-Ying;Hsu, Lee-Ping;Chen, Peir-Rong
通讯作者：
Chen, Peir-Rong
影响因子：
158.5
作者：
Bernier, J;Domenge, C;van Glabbeke, M
通讯作者：
van Glabbeke, M
DOI：
10.1002/hed.10400
发表时间：
2004-08-01
影响因子：
2.9
作者：
Terhaard, CHJ;Lubsen, H;Roodenburg, JLN
通讯作者：
Roodenburg, JLN
影响因子：
1.6
作者：
Chen, Wen-Cheng;Lai, Chia-Hsuan;Chen, Miao-Fen
通讯作者：
Chen, Miao-Fen
影响因子：
2.6
作者：
Lanzer, Martin;Gander, Thomas;Reinisch, Sabine
通讯作者：
Reinisch, Sabine