Impact of body mass index on neuronal fiber bundle lengths among healthy older adults.
Impact of body mass index on neuronal fiber bundle lengths among healthy older adults.
复制标题
健康老年人中体重指数对神经元纤维束长度的影响。
DOI：
10.1007/s11682-013-9230-7
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发表时间：
2013-09
影响因子：
3.2
通讯作者：
Paul, Robert H.
中科院分区：
文献类型：
--
作者：
Bolzenius, Jacob D.;Laidlaw, David H.;Cabeen, Ryan P.;Conturo, Thomas E.;McMichael, Amanda R.;Lane, Elizabeth M.;Heaps, Jodi M.;Salminen, Lauren E.;Baker, Laurie M.;Gunstad, John;Paul, Robert H.
身体质量指数（BMI）的增加与各种有害的健康结果有关，包括认知功能障碍。最近研究肥胖和大脑之间关系的工作显示，BMI升高的个体白色微结构完整性降低，与年龄或共病健康状况无关。然而，高BMI和白色物质纤维束长度（FBL）之间的关系，这代表了一种新的衡量大脑微结构完整性，仍然是未知的。本研究利用基于弥散张量成像（DTI）的定量纤维束成像，调查72名健康老年人（24名男性，48名女性）的BMI和FBL之间的关系。所有参与者年龄在51至85岁之间（M = 63.26，SD = 8.76）。结果显示，BMI升高与颞叶FBL缩短相关，与年龄无关（p <0.01）。此外，年龄增加与较短的额叶、颞叶和全脑FBL相关（所有p值< .01）。这些发现表明，虽然年龄增加是与FBL降低相关的重要因素，但高BMI与颞叶FBL降低唯一相关。这些数据为高BMI对大脑的附加不良影响提供了证据，特别是在已经易受衰老过程和与年龄相关的神经退行性疾病影响的区域。进一步的研究是必要的，以确定与FBL缩短高BMI的个人的生理机制。
Increased body mass index (BMI) has been linked to various detrimental health outcomes, including cognitive dysfunction. Recent work investigating associations between obesity and the brain has revealed decreased white matter microstructural integrity in individuals with elevated BMI, independent of age or comorbid health conditions. However, the relationship between high BMI and white matter fiber bundle length (FBL), which represents a novel metric of microstructural brain integrity, remains unknown. The present study utilized quantitative tractography based on diffusion tensor imaging (DTI) to investigate the relationship between BMI and FBL in 72 otherwise healthy older adults (24 males, 48 females). All participants were between 51 and 85 years of age (M = 63.26, SD = 8.76). Results revealed that elevated BMI was associated with shorter FBL in the temporal lobe, independent of age (p < .01). In addition, increased age was associated with shorter frontal, temporal, and whole brain FBL (all p values < .01). These findings indicate that, while increased age is an important factor associated with reduced FBL, high BMI is uniquely associated with reduced FBL in the temporal lobe. These data offer evidence for additive adverse effects of high BMI on the brain, especially in areas already vulnerable to aging processes and age-related neurodegenerative diseases. Further research is necessary to determine the physiological mechanisms associated with the shortening of FBL in individuals with high BMI.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
5.7
作者：
Barrick, Thomas R.;Charlton, Rebecca A.;Markus, Hugh S.
通讯作者：
Markus, Hugh S.
DOI：
10.1111/j.1365-2370.2004.00476.x
发表时间：
2004-10-01
期刊：
EUROPEAN JOURNAL OF IMMUNOGENETICS
影响因子：
--
作者：
Latkovskis, G;Licis, N;Kalnins, U
通讯作者：
Kalnins, U
影响因子：
2.5
作者：
Marner, L;Nyengaard, JR;Pakkenberg, B
通讯作者：
Pakkenberg, B