Liquid-liquid two-phase systems for the production of porous hydrogels and hydrogel microspheres for biomedical applications: A tutorial review.
Liquid-liquid two-phase systems for the production of porous hydrogels and hydrogel microspheres for biomedical applications: A tutorial review.
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DOI：
10.1016/j.actbio.2010.07.028
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发表时间：
2011-01
影响因子：
9.7
通讯作者：
Elbert DL
中科院分区：
文献类型：
--
作者：
Elbert DL
大孔水凝胶可以作为支持组织形成的支架在再生医学中有直接的应用。水凝胶微球可以用作药物递送载体或作为组装模块化支架的构建块。制备大孔水凝胶和水凝胶微球的技术多种多样。其中一个子集依赖于液-液两相系统。在这个子集中，发现了非常不同类型的聚合过程。本文综述了液-液两相聚合和交联的历史、术语和分类。通过沉淀/分散、乳液和悬浮液聚合形成水凝胶微球和大孔支架的指导性例子来说明这些过程的本质。还描述了相分离动力学在确定支架和微球形态中的作用。简要介绍了微乳液、微乳液聚合和离子化凝胶。
Macroporous hydrogels may have direct applications in regenerative medicine as scaffolds to support tissue formation. Hydrogel microspheres may be used as drug delivery vehicles or as building blocks to assemble modular scaffolds. A variety of techniques exist to produce macroporous hydrogels and hydrogel microspheres. A subset of these relies on liquid-liquid two phase systems. Within this subset, vastly different types of polymerization processes are found. In this review, the history, terminology and classification of liquid-liquid two phase polymerization and crosslinking are described. Instructive examples of hydrogel microsphere and macroporous scaffold formation by precipitation/dispersion, emulsion and suspension polymerizations are used to illustrate the nature of these processes. The role of the kinetics of phase separation in determining the morphology of scaffolds and microspheres is also delineated. Brief descriptions of miniemulsion, microemulsion polymerization and ionotropic gelation are also included.
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影响因子：
14
作者：
Bridges, Amanda W.;Singh, Neetu;Burns, Kellie L.;Babensee, Julia E.;Lyon, L. Andrew;Garcia, Andres J.
通讯作者：
Garcia, Andres J.
影响因子：
3.2
作者：
ARSHADY, R;GEORGE, MH
通讯作者：
GEORGE, MH
影响因子：
--
作者：
Benton JA;DeForest CA;Vivekanandan V;Anseth KS
通讯作者：
Anseth KS
影响因子：
6.3
作者：
Chen, LQ;Shen, J
通讯作者：
Shen, J
影响因子：
3
作者：
Cai, WS;Gupta, RB
通讯作者：
Gupta, RB