Lessons from Microglia Aging for the Link between Inflammatory Bone Disorders and Alzheimer's Disease.
Lessons from Microglia Aging for the Link between Inflammatory Bone Disorders and Alzheimer's Disease.
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DOI：
10.1155/2015/471342
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发表时间：
2015
影响因子：
4.1
通讯作者：
Nakanishi H
中科院分区：
文献类型：
--
作者：
Wu Z;Nakanishi H
骨骼对过度活跃的免疫反应很敏感，它会引发炎症性骨病，如类风湿性关节炎和牙周炎，导致显著的全身炎症反应。另一方面，神经炎症与阿尔茨海默病(AD)密切相关，系统性炎症可能会加剧阿尔茨海默病，如心血管疾病和糖尿病引起的炎症。越来越多的临床证据支持类风湿性关节炎和牙周炎与AD呈正相关的概念，表明炎症性骨病是这种情况的危险因素。最近的研究表明，软脑膜细胞在将全身炎症信号传递给脑内驻留的小胶质细胞方面发挥着重要作用。更重要的是，老年型而不是幼年型的小胶质细胞会引发神经炎症，以应对全身炎症。由于类风湿性关节炎和牙周炎的患病率随着年龄的增长而增加，炎症性骨病可能是老年人隐性全身炎症的重要来源。这篇综述文章强调了我们目前对炎症性骨病和AD之间的联系的理解，特别关注小胶质细胞的老化。
Bone is sensitive to overactive immune responses, which initiate the onset of inflammatory bone disorders, such as rheumatoid arthritis and periodontitis, resulting in a significant systemic inflammatory response. On the other hand, neuroinflammation is strongly implicated in Alzheimer's disease (AD), which can be enhanced by systemic inflammation, such as that due to cardiovascular disease and diabetes. There is growing clinical evidence supporting the concept that rheumatoid arthritis and periodontitis are positively linked to AD, suggesting that inflammatory bone disorders are risk factors for this condition. Recent studies have suggested that leptomeningeal cells play an important role in transducing systemic inflammatory signals to brain-resident microglia. More importantly, senescent-type, but not juvenile-type, microglia provoke neuroinflammation in response to systemic inflammation. Because the prevalence of rheumatoid arthritis and periodontitis increases with age, inflammatory bone disorders may be significant sources of covert systemic inflammation among elderly people. The present review article highlights our current understanding of the link between inflammatory bone disorders and AD with a special focus on microglia aging.
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影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1074/jbc.m113.478545
发表时间：
2013-08-09
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Kanzaki H;Shinohara F;Kajiya M;Kodama T
通讯作者：
Kodama T
影响因子：
--
作者：
Fang, Chuan-Lin;Wu, Wei-Hui;Li, Yan-Mei
通讯作者：
Li, Yan-Mei
影响因子：
5.6
作者：
Kühn, K;Shikhman, AR;Lotz, M
通讯作者：
Lotz, M
影响因子：
158.5
作者：
in 't Veld, BA;Ruitenberg, A;Stricker, BHC
通讯作者：
Stricker, BHC