Spatial working memory in neurofibromatosis 1: Altered neural activity and functional connectivity.
Spatial working memory in neurofibromatosis 1: Altered neural activity and functional connectivity.
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DOI：
10.1016/j.nicl.2017.06.032
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Bearden CE
中科院分区：
文献类型：
--
作者：
Ibrahim AFA;Montojo CA;Haut KM;Karlsgodt KH;Hansen L;Congdon E;Rosser T;Bilder RM;Silva AJ;Bearden CE
1型神经纤维瘤病（NF 1）是一种遗传性疾病，破坏中枢神经系统发育和神经元功能。认知方面，NF 1的特点是执行控制和视觉空间能力的困难。关于这些缺陷背后的神经基质知之甚少。本研究利用血氧水平依赖性（BOLD）功能磁共振成像（fMRI）探讨NF 1患者空间工作记忆（WM）缺陷的神经相关性。BOLD图像采集自23名NF 1成人（年龄M = 32.69; 61%男性）和25名匹配的健康对照（年龄M = 33.08; 64%男性），在扫描仪视觉空间WM任务。全脑功能和心理生理相互作用的分析被用来调查的神经活动和功能连接，分别在视觉空间WM性能。参与者还完成了空间推理和言语WM的行为测量。相对于健康对照组，NF 1参与者表现出WM电路的关键组成部分，左背外侧前额叶皮层和右顶叶皮层的招募减少。此外，健康对照组表现出更大的同时失活之间的后扣带皮层（PCC）和颞区比NF 1患者。相比之下，NF 1患者表现出更大的PCC和双侧顶叶与视觉皮质的连接，以及PCC和小脑之间的连接。在NF 1参与者中，PCC与额叶和顶叶区域的功能耦合增加分别与更好的空间推理和WM表现相关;在对照组中未观察到这些关系。NF 1患者的WM电路功能障碍和“任务阴性”区域的异常功能连接可能是这种疾病的空间WM困难特征的基础。NF 1是一种与执行功能缺陷相关的单基因疾病。与对照组相比，NF 1患者的工作记忆回路活动减退NF 1患者在任务期间与视觉皮层/小脑的PCC连接增加对照组中默认模式区域之间的同时失活增加NF 1患者中PCC-额叶耦合与更好的行为表现相关
Neurofibromatosis Type 1 (NF1) is a genetic disorder that disrupts central nervous system development and neuronal function. Cognitively, NF1 is characterized by difficulties with executive control and visuospatial abilities. Little is known about the neural substrates underlying these deficits. The current study utilized Blood-Oxygen-Level-Dependent (BOLD) functional MRI (fMRI) to explore the neural correlates of spatial working memory (WM) deficits in patients with NF1. BOLD images were acquired from 23 adults with NF1 (age M = 32.69; 61% male) and 25 matched healthy controls (age M = 33.08; 64% male) during an in-scanner visuo-spatial WM task. Whole brain functional and psycho-physiological interaction analyses were utilized to investigate neural activity and functional connectivity, respectively, during visuo-spatial WM performance. Participants also completed behavioral measures of spatial reasoning and verbal WM. Relative to healthy controls, participants with NF1 showed reduced recruitment of key components of WM circuitry, the left dorsolateral prefrontal cortex and right parietal cortex. In addition, healthy controls exhibited greater simultaneous deactivation between the posterior cingulate cortex (PCC) and temporal regions than NF1 patients. In contrast, NF1 patients showed greater PCC and bilateral parietal connectivity with visual cortices as well as between the PCC and the cerebellum. In NF1 participants, increased functional coupling of the PCC with frontal and parietal regions was associated with better spatial reasoning and WM performance, respectively; these relationships were not observed in controls. Dysfunctional engagement of WM circuitry, and aberrant functional connectivity of ‘task-negative’ regions in NF1 patients may underlie spatial WM difficulties characteristic of the disorder. NF1 is a monogenic disorder associated with executive function deficits. Hypoactivity of working memory circuitry in NF1 patients relative to controls Increased PCC connectivity with visual cortex/cerebellum in NF1 patients during task Greater simultaneous deactivation between default mode regions in controls Greater PCC-frontal coupling associated with better behavioral performance in NF1
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影响因子：
64.5
作者：
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通讯作者：
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