Assessing interactions between common genetic variant on 2q35 and hormone receptor status with breast cancer risk: evidence based on 26 studies.
Assessing interactions between common genetic variant on 2q35 and hormone receptor status with breast cancer risk: evidence based on 26 studies.
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评估2Q35上常见遗传变异与乳腺癌风险的激素受体状态之间的相互作用：基于26项研究的证据。
DOI：
10.1371/journal.pone.0069056
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Sun J
中科院分区：
文献类型：
--
作者：
Huang T;Hong J;Lin W;Yang Q;Ni K;Wu Q;Sun J
全基因组关联研究已经确定2 q35-rs 13387042是欧洲血统人群中一个新的乳腺癌（BC）易感基因座。从那时起，2 q35-rs 13387042与乳腺癌之间的关系在各个种族群体中被报道;然而，这些研究得出了不一致的结果。为了研究这种不一致性，我们对26项研究进行了荟萃分析，涉及101，529例病例和167，363例对照，以评估2 q35-rs 13387042多态性对乳腺癌遗传易感性的影响。rs 13387042-A变异体的总体随机效应比值比为1.14（95% CI：1.11-1.16，P<10−5）。使用显性（OR = 1.14，95% CI：1.12-1.17，P<10−5）、隐性（OR = 1.17，95% CI：1.13-1.21，P<10−5）和共显性遗传模型（杂合子：OR = 1.15，95% CI：1.12-1.19，P<10−5;纯合子：OR = 1.20，95% CI：1.15-1.24，P<10−5）也观察到显著结果。 有强有力的证据表明存在异质性，但在按族裔分层后基本上消失了。当按种族分层时，在东亚人和白色人群中发现了显著的相关性;而在非洲人和其他种族人群中没有观察到显著的相关性。观察到ER阳性（OR = 1.17，95%CI：1.15-1.19; P<10−5）和ER阴性疾病（OR = 1.08，95%CI：1.04-1.13; P<10−4）以及孕酮受体（PR）阳性（OR = 1.18，95%CI：1.15-1.21; P<10−5）和PR阴性疾病（OR = 1.10，95%CI：1.05-1.15; P<10−4）两者之间存在关联。 总之，这项荟萃分析表明，2 q35-rs 13387042的A等位基因是与乳腺癌易感性增加相关的危险因素。
Genome-wide association studies have identified 2q35-rs13387042 as a new breast cancer (BC) susceptibility locus in populations of European descent. Since then, the relationship between 2q35-rs13387042 and breast cancer has been reported in various ethnic groups; however, these studies have yielded inconsistent results. To investigate this inconsistency, we performed a meta-analysis of 26 studies involving a total of 101,529 cases and 167,363 controls for 2q35-rs13387042 polymorphism to evaluate its effect on genetic susceptibility for breast cancer. An overall random effects odds ratio of 1.14 (95% CI: 1.11–1.16, P<10−5) was found for rs13387042-A variant. Significant results were also observed using dominant (OR = 1.14, 95% CI: 1.12–1.17, P<10−5), recessive (OR = 1.17, 95% CI: 1.13–1.21, P<10−5) and co-dominant genetic model (heterozygous: OR = 1.15, 95% CI: 1.12–1.19, P<10−5; homozygous: OR = 1.20, 95% CI: 1.15–1.24, P<10−5). There was strong evidence of heterogeneity, which largely disappeared after stratification by ethnicity. Significant associations were found in East Asians, and White populations when stratified by ethnicity; while no significant associations were observed in Africans and other ethnic populations. An association was observed for both ER-positive (OR = 1.17, 95% 1.15–1.19; P<10−5) and ER-negative disease (OR = 1.08, 95% CI: 1.04–1.13; P<10−4) and both progesterone receptor (PR)-positive (OR = 1.18, 95% CI: 1.15–1.21; P<10−5) and PR-negative disease (OR = 1.10, 95% CI: 1.05–1.15; P<10−4). In conclusion, this meta-analysis demonstrated that the A allele of 2q35-rs13387042 is a risk factor associated with increased breast cancer susceptibility.
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DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
DOI：
10.1158/1055-9965.epi-11-0524
发表时间：
2011-09
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Hutter CM;Young AM;Ochs-Balcom HM;Carty CL;Wang T;Chen CT;Rohan TE;Kooperberg C;Peters U
通讯作者：
Peters U
影响因子：
8.8
作者：
Harlid, S.;Ivarsson, M. I. L.;Carlson, J.
通讯作者：
Carlson, J.
影响因子：
3.5
作者：
Chen, Fang;Chen, Gary K.;Haiman, Christopher A.
通讯作者：
Haiman, Christopher A.
影响因子：
4.7
作者：
Huo, Dezheng;Zheng, Yonglan;Olopade, Olufunmilayo I.
通讯作者：
Olopade, Olufunmilayo I.