Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes.
Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes.
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DOI：
10.1002/ajmg.b.31182
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发表时间：
2011-06
影响因子：
2.8
通讯作者：
Woodside, D. Blake
中科院分区：
文献类型：
--
作者：
Jonassaint, Charles R.;Szatkiewicz, Jin Peng;Bulik, Cynthia M.;Thornton, Laura M.;Bloss, Cinnamon;Berrettini, Wade H.;Kaye, Walter H.;Bergen, Andrew W.;Magistretti, Pierre;Strober, Michael;Keel, Pamela K.;Brandt, Harry;Crawford, Steve;Crow, Scott;Fichter, Manfred M.;Goldman, David;Halmi, Katherine A.;Johnson, Craig;Kaplan, Allan S.;Klump, Kelly L.;La Via, Maria;Mitchell, James E.;Rotondo, Alessandro;Treasure, Janet;Woodside, D. Blake
基于大规模人群的全基因组关联研究已经确定了FTO基因与体重指数（BMI）之间的关联；然而，其作用机制仍然未知。为了确定FTO是否可能通过心理和行为因素影响体重调节，对来自国际普赖斯饮食失调遗传学研究的1085名神经性厌食症（AN）患者和677名健康体重对照者的FTO基因的7个单核苷酸多态性（SNP）进行了基因分型。每个SNP都与饮食失调表型以及先前与饮食行为病理学相关的指标进行了关联测试：特质焦虑、伤害回避、新奇寻求、冲动性、强迫性、强迫行为以及对错误的担忧。在对多重比较进行适当校正后，在病例组或对照组中，未发现单个FTO基因SNP与饮食失调表型或相关饮食行为病理学之间存在显著关联。因此，这项研究没有发现证据表明在普通人群中与体重调节相关的FTO基因变异与神经性厌食症参与者或匹配对照组的饮食失调表型有关。
Extensive population-based genome-wide association studies have identified an association between the FTO gene and BMI; however, the mechanism of action is still unknown. To determine whether FTO may influence weight regulation through psychological and behavioral factors, seven single nucleotide polymorphisms (SNPs) of the FTO gene were genotyped in 1085 individuals with anorexia nervosa (AN) and 677 healthy weight controls from the international Price Foundation Genetic Studies of Eating Disorders. Each SNP was tested in association with eating disorder phenotypes and measures that have previously been associated with eating behavior pathology: trait anxiety, harm-avoidance, novelty seeking, impulsivity, obsessionality, compulsivity, and concern over mistakes. After appropriate correction for multiple comparisons, no significant associations between individual FTO gene SNPs and eating disorder phenotypes or related eating behavior pathology were identified in cases or controls. Thus, this study found no evidence that FTO gene variants associated with weight regulation in the general population are associated with eating disorder phenotypes in AN participants or matched controls.
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影响因子：
158.5
作者：
Cecil, Joanne E.;Tavendale, Roger;Palmer, Colin N. A.
通讯作者：
Palmer, Colin N. A.
影响因子：
3
作者：
AKAIKE, H
通讯作者：
AKAIKE, H
影响因子：
6.9
作者：
GARNER, DM;OLMSTED, MP;GARFINKEL, PE
通讯作者：
GARFINKEL, PE
DOI：
10.1198/016214501753382129
发表时间：
2001-12-01
影响因子：
3.7
作者：
Efron, B;Tibshirani, R;Tusher, V
通讯作者：
Tusher, V
影响因子：
7.7
作者：
Do, Ron;Bailey, Swneke D.;Engert, James C.
通讯作者：
Engert, James C.