Metabolism of oxygen via T(2) and interleaved velocity encoding: A rapid method to quantify whole-brain cerebral metabolic rate of oxygen.
Metabolism of oxygen via T(2) and interleaved velocity encoding: A rapid method to quantify whole-brain cerebral metabolic rate of oxygen.
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DOI：
10.1002/mrm.29299
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发表时间：
2022-09
影响因子：
3.3
通讯作者：
Wehrli, Felix W.
中科院分区：
文献类型：
--
作者：
Deshpande, Rajiv S.;Langham, Michael C.;Cheng, Cheng-Chieh;Wehrli, Felix W.
脑氧代谢率（CMRO2）是脑功能的重要生物标志物。量化 CMRO2 所需的关键生理参数包括供血动脉中的血流量和引流静脉中的静脉氧饱和度 (SvO2)。这里，开发了一种脉冲序列，即通过 T2 和交错速度编码进行的氧代谢 (MOTIVE)，以同时测量这两个参数并在单次传递中实现 CMRO2 量化。 MOTIVE 在非选择性饱和度和背景抑制 T2 准备的 EPI 读数 (BGS-EPI) 之间插入相差模块，可在 20 秒或更短的时间内测量血液质子的 T2 和脑血流量 (CBF)。将 MOTIVE 和独立 BGS-EPI 与健康受试者 (n=24) 大脑中的 TRUST 进行比较。探索了提高分辨率或缩短扫描时间的 MOTIVE 变体。进行了会话内和会话间的再现性研究。 MOTIVE 实验得出大脑上矢状窦的平均 SvO2 为 61 ± 6%，平均 CBF 为 56 ± 10 mL/min/100g。 MOTIVE 和 BGS-EPI 的 SvO2 相对于 TRUST 的偏差分别为 +2 ± 4% 和 +1 ± 3%。 MOTIVE 的 CBF 相对于笛卡尔相位对比参考的偏差为 +1 ± 6 mL/min/100g。 MOTIVE 是现有基于 T2 的血氧测定方法的进步。它不需要控制图像并同时测量 SvO2 和流速。测量结果与 TRUST 和参考相位对比序列非常吻合。这种非侵入性技术可在 20 秒内实现 CMRO2 定量，并且可在体内应用中重现。
Cerebral metabolic rate of oxygen (CMRO2) is an important biomarker of brain function. Key physiological parameters required to quantify CMRO2 include blood flow rate in feeding arteries and venous oxygen saturation (SvO2) in the draining vein. Here, a pulse sequence, Metabolism of Oxygen via T2 and Interleaved Velocity Encoding (MOTIVE), was developed to measure both parameters simultaneously and enable CMRO2 quantification in a single pass. MOTIVE interleaves a phase-contrast module between a non-selective saturation and a background-suppressed T2-prepared EPI readout (BGS-EPI) to measure T2 of blood water protons and cerebral blood flow (CBF) in 20 seconds or less. MOTIVE and standalone BGS-EPI were compared against TRUST in the brain in healthy subjects (n=24). Variants of MOTIVE to enhance resolution or shorten scan time were explored. Intra- and inter-session reproducibility studies were performed. MOTIVE experiments yielded an average SvO2 of 61 ± 6% in the superior sagittal sinus of the brain and an average CBF of 56 ± 10 mL/min/100g. The bias in SvO2 of MOTIVE and BGS-EPI to TRUST was +2 ± 4% and +1 ± 3%, respectively. The bias in CBF of MOTIVE to Cartesian phase-contrast reference was +1 ± 6 mL/min/100g. MOTIVE is an advance over existing T2-based oximetric methods. It does not require a control image and simultaneously measures SvO2 and flow velocity. The measurements agree well with TRUST and reference phase-contrast sequences. This noninvasive technique enables CMRO2 quantification in under 20 seconds and is reproducible for in vivo applications.
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影响因子：
3.3
作者：
Jiang, Dengrong;Deng, Shengwen;Franklin, Crystal G.;O'Boyle, Michael;Zhang, Wei;Heyl, Betty L.;Pan, Li;Jerabek, Paul A.;Fox, Peter T.;Lu, Hanzhang
通讯作者：
Lu, Hanzhang
影响因子：
3.3
作者：
Foltz, WD;Stainsby, JA;Wright, GA
通讯作者：
Wright, GA
影响因子：
3.3
作者：
Magland JF;Li C;Langham MC;Wehrli FW
通讯作者：
Wehrli FW
影响因子：
3.3
作者：
He, Xiang;Yablonskiy, Dmitriy A.
通讯作者：
Yablonskiy, Dmitriy A.
影响因子：
2.2
作者：
HAACKE, EM;LINDSKOG, ED;LIN, W
通讯作者：
LIN, W