Genetic dissection of behavioral traits related to successful training of drug detection dogs.
Genetic dissection of behavioral traits related to successful training of drug detection dogs.
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DOI：
10.1038/s41598-023-33638-6
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发表时间：
2023-05-05
影响因子：
4.6
通讯作者：
Inoue-Murayama, Miho
中科院分区：
文献类型：
--
作者：
Matsumoto, Yuki;Konno, Akitsugu;Ishihara, Genki;Inoue-Murayama, Miho
缉毒犬在社会中发挥着重要作用。然而，他们的行为和遗传特征之间的相互作用，他们的表现仍然没有调查。在此，在326只德国牧羊犬或拉布拉多犬中评估了超过120，000种遗传变异，以分析与成功训练毒品检测犬相关的各种行为特征相关的遗传特征。行为品种的差异被观察到在“对人类的友好”和“对狗的宽容”。两个品种的全基因组关联研究确定了11个可能与药物检测犬特征相关的区域，以及与药物检测能力相关的“对目标感兴趣”和“对人类友好”。其中，63个蛋白质编码基因，包括已知分别与小鼠焦虑相关或探索行为相关的Atat 1和Pfn 2，位于已确定的候选多态性周围。这项研究强调了与行为特征相关的遗传特征，这些特征对成功训练缉毒犬很重要。因此，这些发现可能有助于改善这些狗的繁殖和训练。
Drug detection dogs play integral roles in society. However, the interplay between their behaviors and genetic characteristics underlying their performance remains uninvestigated. Herein, more than 120,000 genetic variants were evaluated in 326 German Shepherd or Labrador Retriever dogs to profile the genetic traits associated with various behavioral traits related to the successful training of drug detection dogs. Behavioral breed differences were observed in ‘friendliness to humans’ and ‘tolerance to dogs.’ A genome-wide association study within both breeds identified 11 regions potentially associated with drug detection dog characteristics as well as ‘interest in the target’ and ‘friendliness to humans,’ which are related to drug detection abilities. Among them, 63 protein-coding genes, including Atat1 and Pfn2 known to be associated with anxiety-related or exploration behavior in mice, respectively, were located surrounding the identified candidate polymorphisms. This study highlights genetic characteristics associated with behavioral traits that are important for the successful training of drug detection dogs. Thus, these findings may facilitate improved breeding and training of these dogs.
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影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
2.3
作者：
Slabbert, JM;Odendaal, JSJ
通讯作者：
Odendaal, JSJ
影响因子：
2.4
作者：
Marras, Gabriele;Gaspa, Giustino;Macciotta, Nicolo P. P.
通讯作者：
Macciotta, Nicolo P. P.
影响因子：
2.3
作者：
Maejima, Masami;Inoue-Murayama, Miho;Ito, Shin'ichi
通讯作者：
Ito, Shin'ichi
影响因子：
3.1
作者：
Niimi, Y;Inoue-Murayama, M;Iwasaki, T
通讯作者：
Iwasaki, T