Rift Valley fever virus(Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention.
Rift Valley fever virus(Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention.
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DOI：
10.1051/vetres/2010033
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发表时间：
2010-11
影响因子：
4.4
通讯作者：
Paweska J
中科院分区：
文献类型：
--
作者：
Pepin M;Bouloy M;Bird BH;Kemp A;Paweska J
裂谷热病毒是布尼亚病毒科的一种虫媒病毒，从系统发育分析来看，它似乎最早出现于19世纪中期，直到20世纪30年代末才在肯尼亚的裂谷地区被发现。尽管这是一种虫媒病毒，基因组相对简单，但在时间和地理上稳定，但这种人畜共患病毒已经表现出真实的在新地区出现的能力，例如在埃及（1977年）、西非（1988年）和阿拉伯半岛（2000年）的爆发，或在长期沉默后重新出现，如最近在肯尼亚和南非观察到的。在以前没有裂谷热的国家出现了有能力的病媒，患病毒病的动物体内病毒滴度很高，以及气候、旅行和贸易方面的全球变化，所有这些都促使该病毒成为一种不容忽视的威胁，因为裂谷热对人类和动物健康都造成了严重后果。本文综述了裂谷热病毒研究的最新进展。尽管重新引起了人们的兴趣，但人们对裂谷热病毒的流行病学仍不完全了解，仍不能免费提供安全有效的疫苗，保护人类和牲畜免受这一病毒的严重后果。
Rift Valley fever (RVF) virus is an arbovirus in the Bunyaviridae family that, from phylogenetic analysis, appears to have first emerged in the mid-19th century and was only identified at the begininning of the 1930s in the Rift Valley region of Kenya. Despite being an arbovirus with a relatively simple but temporally and geographically stable genome, this zoonotic virus has already demonstrated a real capacity for emerging in new territories, as exemplified by the outbreaks in Egypt (1977), Western Africa (1988) and the Arabian Peninsula (2000), or for re-emerging after long periods of silence as observed very recently in Kenya and South Africa. The presence of competent vectors in countries previously free of RVF, the high viral titres in viraemic animals and the global changes in climate, travel and trade all contribute to make this virus a threat that must not be neglected as the consequences of RVF are dramatic, both for human and animal health. In this review, we present the latest advances in RVF virus research. In spite of this renewed interest, aspects of the epidemiology of RVF virus are still not fully understood and safe, effective vaccines are still not freely available for protecting humans and livestock against the dramatic consequences of this virus.
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