Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet.
Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet.
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DOI：
10.1016/j.ceb.2014.06.005
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发表时间：
2014-10
影响因子：
7.5
通讯作者：
Haugh, Jason M.
中科院分区：
文献类型：
--
作者：
Bear, James E.;Haugh, Jason M.
由空间线索或趋化引导的细胞迁移是发育、伤口修复和免疫反应期间协调一致和集体细胞运动的主要机制。与阿米巴样趋化性的经典例子相比，其中快速移动的细胞如中性粒细胞由可溶性因子的梯度引导，定向迁移的缓慢移动的间充质细胞如成纤维细胞知之甚少。间充质细胞具有肌动蛋白细胞骨架和相关粘附复合物的独特组织作为其主要的机械系统，产生运动所需的不对称力而没有强烈的极化。新出现的假说是，间充质细胞趋化的分子基础涉及不同的信号通路和不同的调节要求。
Cell migration directed by spatial cues, or taxis, is a primary mechanism for orchestrating concerted and collective cell movements during development, wound repair, and immune responses. Compared with the classic example of amoeboid chemotaxis, in which fast-moving cells such as neutrophils are directed by gradients of soluble factors, directed migration of slow-moving mesenchymal cells such as fibroblasts is poorly understood. Mesenchymal cells possess a distinctive organization of the actin cytoskeleton and associated adhesion complexes as its primary mechanical system, generating the asymmetric forces required for locomotion without strong polarization. The emerging hypothesis is that the molecular underpinnings of mesenchymal taxis involve distinct signaling pathways and diverse requirements for regulation.
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DOI：
10.1038/nrm2867
发表时间：
2010-04
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.2
作者：
Allen, Greg M.;Mogilner, Alex;Theriot, Julie A.
通讯作者：
Theriot, Julie A.
影响因子：
64.8
作者：
Dang, Irene;Gorelik, Roman;Gautreau, Alexis
通讯作者：
Gautreau, Alexis
影响因子：
3.4
作者：
Haugh, JM
通讯作者：
Haugh, JM
影响因子：
3.2
作者：
Edelberg, Jay M;Cai, Dongqing;Xaymardan, Munira
通讯作者：
Xaymardan, Munira