Regulatory and activated T cells in human Schistosoma haematobium infections.
Regulatory and activated T cells in human Schistosoma haematobium infections.
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DOI：
10.1371/journal.pone.0016860
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发表时间：
2011-02-10
期刊：
影响因子：
3.7
通讯作者：
Mutapi F
中科院分区：
文献类型：
--
作者：
Nausch N;Midzi N;Mduluza T;Maizels RM;Mutapi F
针对蠕虫的获得性免疫的特征在于效应子Th 1和Th 2免疫应答之间的复杂相互作用，并且由于累积暴露于寄生虫抗原，其随着年龄的增长而缓慢显现。来自实验模型的数据表明，免疫力也受到调节性T细胞（Treg）的影响，但迄今为止，对人类染色体感染中Treg的研究有限。本研究调查了津巴布韦人暴露于埃及血吸虫寄生虫后，两种细胞群调节性T细胞（Treg：CD 4+（dim）CD 25+（high）FOXP 3 + CD 127 low）和活化性T细胞（Tact：CD 4 + CD 25 + FOXP 3 −）之间的关系。参与者被分为两个年龄组，幼儿（8-13岁）的感染水平上升到高峰，老年人（14岁以上）的感染水平下降。Tact比例与病原体感染强度之间的关系随年龄的增长而保持不变。然而，Treg比例随着较年轻年龄组感染的增加而显着上升。相反，Treg与老年组的感染强度呈负相关。调节性T细胞的相对比例在高感染与增强的调节表型相关的年轻个体和调节反应减弱的老年感染患者之间显著不同。这可能会影响或反映不同阶段的发展保护性的自体获得性免疫和免疫发病机制。
Acquired immunity against helminths is characterised by a complex interplay between the effector Th1 and Th2 immune responses and it slowly manifests with age as a result of cumulative exposure to parasite antigens. Data from experimental models suggest that immunity is also influenced by regulatory T cells (Treg), but as yet studies on Treg in human schistosome infections are limited. This study investigated the relationship between schistosome infection intensity and the two cell populations regulatory T cells (Treg: CD4+(dim)CD25+(high)FOXP3+CD127low), and activated (Tact: CD4+CD25+FOXP3−) T cells in Zimbabweans exposed to Schistosoma haematobium parasites. Participants were partitioned into two age groups, young children (8–13 years) in whom schistosome infection levels were rising to peak and older people (14+ years) with declining infection levels. The relationship between Tact proportions and schistosome infection intensity remained unchanged with age. However Treg proportions rose significantly with increasing infection in the younger age group. In contrast Treg were negatively correlated to infection intensity in the older age group. The relative proportions of regulatory T cells differ significantly between young individuals in whom high infection is associated with an enhanced regulatory phenotype and older infected patients in whom the regulatory response is attenuated. This may influence or reflect different stages of the development of protective schistosome acquired immunity and immunopathogenesis.
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影响因子：
4.4
作者：
Mduluza, T;Ndhlovu, PD;Hagan, P
通讯作者：
Hagan, P
影响因子：
3.8
作者：
Everts B;Adegnika AA;Kruize YC;Smits HH;Kremsner PG;Yazdanbakhsh M
通讯作者：
Yazdanbakhsh M
DOI：
10.4049/jimmunol.1000423
发表时间：
2010-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fulton RB;Meyerholz DK;Varga SM
通讯作者：
Varga SM
DOI：
10.1590/s0100-879x1998000100024
发表时间：
1998-01-01
影响因子：
2.3
作者：
Correa-Oliveira, R;Malaquias, LCC;Gazzinelli, G
通讯作者：
Gazzinelli, G
影响因子：
4.4
作者：
McKee, AS;Pearce, EJ
通讯作者：
Pearce, EJ