Monoclonal origin of anatomically distinct basal cell carcinomas.
Monoclonal origin of anatomically distinct basal cell carcinomas.
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解剖学上不同的基底细胞癌的单克隆起源。
DOI：
10.1038/sj.jid.5700130
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
E. Friedman
中科院分区：
文献类型：
--
作者：
Ori Shulman;Y. Laitman;A. Vilan;A. Leviav;E. Friedman
基底细胞癌（BCC）是白种人最常见的皮肤肿瘤。9号染色体（9q22.3）的杂合性缺失（LOH）在bcc中很常见，间接暗示了它们的单克隆起源。虽然bcc被认为是单克隆肿瘤，但在同一患者中解剖上不同的肿瘤的克隆起源很少被研究。对来自15例女性患者的41例解剖学上不同的bcc进行了9q22.3染色体LOH基因分型，并利用雄激素受体多态性位点对x染色体失活模式进行了分型。总体而言，30例肿瘤患者中有11例存在9q标记或雄激素受体多态性的杂合子（信息丰富）。在来自7例患者的20个肿瘤中检测到9q的LOH，并且在来自同一患者的所有肿瘤中，相同的等位基因丢失。从一个病人身上取下的四个肿瘤中发现了相同的x染色体失活模式，在另一个信息丰富的病人身上，一个肿瘤表现出LOH，另一个保留了LOH。在两名患者的5个肿瘤中，使用任何一种技术都没有单克隆的证据。我们得出结论，大多数解剖学上不同的bcc是单克隆肿瘤，可能代表同一克隆的扩增。
Basal cell carcinoma (BCC) is the most common skin tumor in Caucasians. Loss of heterozygosity (LOH) of chromosome 9 (9q22.3) is common in BCCs, and indirectly implies their monoclonal origin. Although BCCs are considered monoclonal tumors, the clonal origin of anatomically distinct tumors in the same patient was rarely investigated. Forty-one anatomically distinct BCCs from 15 female patients were genotyped for LOH at chromosome 9q22.3, and the inactivation pattern of X-chromosome using the androgen receptor polymorphic site. Overall, 11 women with 30 tumors were heterozygous (informative) with either one of the two 9q markers or the androgen receptor polymorphism. LOH of 9q was detected in 20 tumors from seven patients, and in all tumors derived from the same patient, the same allele was lost. An identical X-chromosome inactivation pattern was noted in all four tumors taken from one patient, and in another informative patient, one tumor demonstrated LOH and the other retained it. In five tumors from two patients, there was no evidence of monoclonality using either technique. We conclude that the majority of anatomically distinct BCCs are monoclonal neoplasms and may represent expansion of the same clone.
基底细胞癌的克隆性——一个有趣病例的分子分析。
DOI：
10.1111/1523-1747.ep12344982
发表时间：
1996
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Walsh,DS;Tsou,HC;Harrington,A;James,WD;Peacocke,M
通讯作者：
Peacocke,M
影响因子：
11.2
作者：
B. Vogelstein;E. Fearon;S. Hamilton;A. C. Preisinger;H. Willard;A. Michelson;A. Riggs;S. Orkin
通讯作者：
B. Vogelstein;E. Fearon;S. Hamilton;A. C. Preisinger;H. Willard;A. Michelson;A. Riggs;S. Orkin
散发性基底细胞癌中 X 染色体失活的模式：克隆性的证据。
影响因子：
13.8
作者：
Walsh,DS;Peacocke,M;Harrington,A;James,WD;Tsou,HC
通讯作者：
Tsou,HC