MR Vascular Fingerprinting in Stroke and Brain Tumors Models.
MR Vascular Fingerprinting in Stroke and Brain Tumors Models.
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DOI：
10.1038/srep37071
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发表时间：
2016-11-24
影响因子：
4.6
通讯作者：
Christen T
中科院分区：
文献类型：
--
作者：
Lemasson B;Pannetier N;Coquery N;Boisserand LSB;Collomb N;Schuff N;Moseley M;Zaharchuk G;Barbier EL;Christen T
In this study, we evaluated an MRI fingerprinting approach (MRvF) designed to provide high-resolution parametric maps of the microvascular architecture (i.e., blood volume fraction, vessel diameter) and function (blood oxygenation) simultaneously. The method was tested in rats (n = 115), divided in 3 models: brain tumors (9 L, C6, F98), permanent stroke, and a control group of healthy animals. We showed that fingerprinting can robustly distinguish between healthy and pathological brain tissues with different behaviors in tumor and stroke models. In particular, fingerprinting revealed that C6 and F98 glioma models have similar signatures while 9 L present a distinct evolution. We also showed that it is possible to improve the results of MRvF and obtain supplemental information by changing the numerical representation of the vascular network. Finally, good agreement was found between MRvF and conventional MR approaches in healthy tissues and in the C6, F98, and permanent stroke models. For the 9 L glioma model, fingerprinting showed blood oxygenation measurements that contradict results obtained with a quantitative BOLD approach. In conclusion, MR vascular fingerprinting seems to be an efficient technique to study microvascular properties in vivo. Multiple technical improvements are feasible and might improve diagnosis and management of brain diseases.
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影响因子：
6.3
作者：
Coquery, Nicolas;Francois, Olivier;Barbier, Emmanuel Luc
通讯作者：
Barbier, Emmanuel Luc
影响因子：
11.2
作者：
C치rdenas-Navia, LI;Yu, DH;Dewhirst, MW
通讯作者：
Dewhirst, MW
DOI：
10.1002/wsbm.1295
发表时间：
2015-05
影响因子：
7.9
作者：
Rieger, Heiko;Welter, Michael
通讯作者：
Welter, Michael
影响因子：
3.3
作者：
He, Xiang;Yablonskiy, Dmitriy A.
通讯作者：
Yablonskiy, Dmitriy A.
影响因子：
5.7
作者：
Christen T;Pannetier NA;Ni WW;Qiu D;Moseley ME;Schuff N;Zaharchuk G
通讯作者：
Zaharchuk G