Integrative models of vascular remodeling during tumor growth.
Integrative models of vascular remodeling during tumor growth.
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DOI：
10.1002/wsbm.1295
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发表时间：
2015-05
影响因子：
7.9
通讯作者：
Welter, Michael
中科院分区：
文献类型：
--
作者：
Rieger, Heiko;Welter, Michael
Malignant solid tumors recruit the blood vessel network of the host tissue for nutrient supply, continuous growth, and gain of metastatic potential. Angiogenesis (the formation of new blood vessels), vessel cooption (the integration of existing blood vessels into the tumor vasculature), and vessel regression remodel the healthy vascular network into a tumor-specific vasculature that is in many respects different from the hierarchically organized arterio-venous blood vessel network of the host tissues. Integrative models based on detailed experimental data and physical laws implement in silico the complex interplay of molecular pathways, cell proliferation, migration, and death, tissue microenvironment, mechanical and hydrodynamic forces, and the fine structure of the host tissue vasculature. With the help of computer simulations high-precision information about blood flow patterns, interstitial fluid flow, drug distribution, oxygen and nutrient distribution can be obtained and a plethora of therapeutic protocols can be tested before clinical trials. In this review, we give an overview over the current status of integrative models describing tumor growth, vascular remodeling, blood and interstitial fluid flow, drug delivery, and concomitant transformations of the microenvironment. © 2015 The Authors. WIREs Systems Biology and Medicine published by Wiley Periodicals, Inc.
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影响因子：
2
作者：
Bartha, K.;Rieger, H.
通讯作者：
Rieger, H.
影响因子：
2
作者：
Cai, Yan;Xu, Shixiong;Long, Quan
通讯作者：
Long, Quan
影响因子：
2
作者：
Basan, Markus;Prost, Jacques;Elgeti, Jens
通讯作者：
Elgeti, Jens
DOI：
10.1073/pnas.1219937110
发表时间：
2013-02-12
影响因子：
11.1
作者：
Basan, Markus;Elgeti, Jens;Levine, Herbert
通讯作者：
Levine, Herbert
影响因子：
3.4
作者：
Brú, A;Albertos, S;Brú, I
通讯作者：
Brú, I