The Application of Mechanical Stimulations in Tendon Tissue Engineering.
The Application of Mechanical Stimulations in Tendon Tissue Engineering.
复制标题
机械刺激在肌腱组织工程中的应用
DOI：
10.1155/2020/8824783
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发表时间：
2020
影响因子：
4.3
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Sheng R;Jiang Y;Backman LJ;Zhang W;Chen J
肌腱损伤是肌肉骨骼系统最常见的疾病。目前的治疗方法有许多局限性，如治疗效果差、供区功能丧失、免疫排斥等。肌腱组织工程为肌腱修复和再生提供了一种新的治疗策略。本文对机械刺激在肌腱组织工程中的应用进行了回顾分析，并对其作为未来临床治疗策略的发展方向进行了展望。为此，讨论了以下主题：(1)肌腱组织工程和机械刺激的背景；(2)各种机械刺激在肌腱组织工程中的应用及其内在机制；(3)磁力的应用以及机械刺激和生化刺激的协同作用。我们的目的是澄清目前肌腱组织工程领域存在的一些主要问题，从而获得新的知识，有助于未来组织工程在肌腱损伤中的临床应用。
Tendon injury is the most common disease in the musculoskeletal system. The current treatment methods have many limitations, such as poor therapeutic effects, functional loss of donor site, and immune rejection. Tendon tissue engineering provides a new treatment strategy for tendon repair and regeneration. In this review, we made a retrospective analysis of applying mechanical stimulation in tendon tissue engineering, and its potential as a direction of development for future clinical treatment strategies. For this purpose, the following topics are discussed; (1) the context of tendon tissue engineering and mechanical stimulation; (2) the applications of various mechanical stimulations in tendon tissue engineering, as well as their inherent mechanisms; (3) the application of magnetic force and the synergy of mechanical and biochemical stimulation. With this, we aim at clarifying some of the main questions that currently exist in the field of tendon tissue engineering and consequently gain new knowledge that may help in the development of future clinical application of tissue engineering in tendon injury.
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影响因子：
2.9
作者：
Chen, Yi-Jane;Huang, Chien-Hsun;Young, Tai-Horng
通讯作者：
Young, Tai-Horng
影响因子：
4.3
作者：
Burk J;Plenge A;Brehm W;Heller S;Pfeiffer B;Kasper C
通讯作者：
Kasper C
影响因子：
--
作者：
Chen JW;Galloway JL
通讯作者：
Galloway JL
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影响因子：
5.2
作者：
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通讯作者：
Zhou, Yi Ting
影响因子：
4.1
作者：
Barber, John G.;Handorf, Andrew M.;Li, Wan-Ju
通讯作者：
Li, Wan-Ju