Increased Serum Matrix Metalloproteinase-9 Levels are Associated with Anti-Jo1 but not Anti-MDA5 in Myositis Patients
Increased Serum Matrix Metalloproteinase-9 Levels are Associated with Anti-Jo1 but not Anti-MDA5 in Myositis Patients
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肌炎患者血清基质金属蛋白酶 9 水平升高与抗 Jo1 相关，但与抗 MDA5 无关
DOI：
10.14336/ad.2018.1120
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发表时间：
2019-08
影响因子：
7.4
通讯作者：
Huali Zhang
中科院分区：
文献类型：
--
作者：
Yanjuan Liu;Hui Luo;Li Wang;Caiyan Li;Liyun Liu;Li Huang;Ke Liu;Meidong Liu;Siming Gao;Yizhi Xiao;Honglin Zhu;Xiaoxia Zuo;Quan-Zhen Li;Huali Zhang
Matrix metalloproteinases 9 (MMP9) is a member of the zinc-ion-dependent proteinases family and plays a pathogenic role in chronic inflammatory autoimmune diseases. However, its roles in the pathogenesis of myositis have not been elucidated. In this study, we aimed to determine the gene expression and serum level of MMP9 and their relationship with clinical features and serological parameters in myositis. Our results showed that MMP9 mRNA in peripheral blood mononuclear cells (PBMC) was upregulated in myositis patients compared to that in healthy controls. Myositis patients positive for anti-Jo1 antibodies exhibited significantly higher serum MMP9 than anti-MDA5 positive or antibody-negative patients and healthy controls. However, the presence of interstitial lung disease (ILD) did not affect MMP9 levels. We further identified that anti-Jo1-positive myositis patients showed higher numbers of white blood cells (WBC), lymphocytes and neutrophils; increased levels of creatine kinase (CK), lactate dehydrogenase (LDH), and C-reactive protein (CRP); and higher erythrocyte sedimentation rate (ESR) than anti-MDA5 positive patients. In addition, serum MMP-9 levels were positively correlated with WBCs, neutrophils, CK, CRP, ESR, and LDH in myositis patients. In vitro experiments showed that purified serum IgG from Jo-1-positive patients could stimulate PBMCs to release more MMP9 than the IgG from MDA-5-positive sera. These results indicated that increased MMP9 in anti-Jo1-positive myositis patients was associated with the extent of muscle involvement, but not pulmonary damage. The distinct pattern of serum MMP9 perhaps clarifies the differences in pathophysiology between anti-Jo1 and anti-MDA5 in patients with myositis.
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影响因子：
3.7
作者：
Kim Y;Remacle AG;Chernov AV;Liu H;Shubayev I;Lai C;Dolkas J;Shiryaev SA;Golubkov VS;Mizisin AP;Strongin AY;Shubayev VI
通讯作者：
Shubayev VI
DOI：
10.1186/s12948-018-0084-9
发表时间：
2018
期刊：
Clinical and molecular allergy : CMA
影响因子：
--
作者：
Palterer B;Vitiello G;Carraresi A;Giudizi MG;Cammelli D;Parronchi P
通讯作者：
Parronchi P
影响因子：
3.5
作者：
C. Rodolico;A. Mazzeo;A. Toscano;S. Messina;M. Aguennouz;M. Gaeta;C. Messina;G. Vita
通讯作者：
C. Rodolico;A. Mazzeo;A. Toscano;S. Messina;M. Aguennouz;M. Gaeta;C. Messina;G. Vita
影响因子：
27.4
作者：
Tchetverikov, I;Lard, LR;Hanemaaijer, R
通讯作者：
Hanemaaijer, R
DOI：
10.1191/1352458502ms800oa
发表时间：
2002-05-01
期刊：
MULTIPLE SCLEROSIS
影响因子：
--
作者：
Liuzzi, GM;Trojano, M;Riccio, P
通讯作者：
Riccio, P