Osteoblasts: a novel source of erythropoietin.
Osteoblasts: a novel source of erythropoietin.
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DOI:
10.1007/s11914-014-0236-x
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发表时间:
2014-12
影响因子:
4.3
通讯作者:
Rankin, Erinn B.
中科院分区:
文献类型:
--
作者:
Wu, Colleen;Giaccia, Amato J.;Rankin, Erinn B.
Osteoblasts are an important cellular component of the bone microenvironment controlling bone formation and hematopoiesis. Understanding the cellular and molecular mechanisms by which osteoblasts regulate these processes is a rapidly growing area of research given the important implications for bone therapy, regenerative medicine, and hematopoietic stem cell transplantation. Here we summarize our current knowledge regarding the cellular and molecular crosstalk driving bone formation and hematopoiesis and will discuss the implications of a recent finding demonstrating that osteoblasts are a cellular source of erythropoietin.
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