Correlations of inflammatory gene pathways, corticolimbic functional activities, and aggression in pediatric bipolar disorder: a preliminary study.
Correlations of inflammatory gene pathways, corticolimbic functional activities, and aggression in pediatric bipolar disorder: a preliminary study.
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DOI：
10.1016/j.pscychresns.2014.07.009
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发表时间：
2014-11-30
影响因子：
11.3
通讯作者：
Lin PI
中科院分区：
文献类型：
--
作者：
Barzman D;Eliassen J;McNamara R;Abonia P;Mossman D;Durling M;Adler C;DelBello M;Lin PI
双相情感障碍青少年攻击行为的潜在机制一直知之甚少。本研究探讨了双相情感障碍青少年中TNF基因表达、挫折性非奖赏任务下脑功能激活和攻击性之间的关系。基线基因表达和攻击倾向分别用RNA测序和儿童和青少年攻击性简要评定（BRACHA）进行测量。我们的研究结果表明，左侧膝下前扣带回（ACG）、右侧杏仁核、左侧布罗德曼10区（眶额皮质）和右侧丘脑的活动水平与BRACHA评分呈负相关，并且在情感波斯纳任务期间因挫败性非奖励而被激活。此外，11个TNF相关基因的表达与杏仁核或ACG的激活在情感Posner任务中显着相关。3个TNF基因表达与BRACHA评分呈负相关，1个TNF基因（TNFAIP3）表达与BRACHA评分呈正相关。因此，肿瘤坏死因子相关的炎症细胞因子基因可能在儿童双相情感障碍中与挫折性非奖励和攻击行为相关的神经活动中发挥作用。
The mechanisms underlying aggression in adolescents with bipolar disorder have been poorly understood. The present study has investigated the associations among TNF gene expressions, functional brain activations under the frustrative non-reward task, and aggression in adolescents with bipolar disorder. Baseline gene expressions and aggressive tendencies were measured with the RNA-sequencing and Brief Rating of Aggression by Children and Adolescents (BRACHA), respectively. Our results show that activity levels of left subgenual anterior cingulate gyrus (ACG) right amygdala, left Brodmann area 10 (orbitofrontal cortex), and right thalamus were inversely correlated with BRACHA scores and were activated with frustrative non-reward during the affective Posner Task. In addition, eleven TNF related gene expressions were significantly correlated with activation of amygdala or ACG during the affective Posner task. Three TNF gene expressions were inversely correlated with BRACHA score while one TNF gene (TNFAIP3) expression was positively correlated with BRACHA score. Therefore, TNF-related inflammatory cytokine genes may play a role in neural activity associated with frustrative non-reward and aggressive behaviors in pediatric bipolar disorder.
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影响因子：
3.3
作者：
Hong, J;Zang, YCQ;Zhang, JWZ
通讯作者：
Zhang, JWZ
影响因子：
1
作者：
Lotrich FE;Ferrell RE;Rabinovitz M;Pollock BG
通讯作者：
Pollock BG
影响因子：
7.6
作者：
GOYER, PF;COHEN, RM;SCHULZ, SC
通讯作者：
SCHULZ, SC
影响因子：
5.4
作者：
Perlis RH;Dennehy EB;Miklowitz DJ;Delbello MP;Ostacher M;Calabrese JR;Ametrano RM;Wisniewski SR;Bowden CL;Thase ME;Nierenberg AA;Sachs G
通讯作者：
Sachs G
影响因子：
3.1
作者：
Dargahi, Leila;Nasiraei-Moghadam, Shiva;Ahmadiani, Abolhassan
通讯作者：
Ahmadiani, Abolhassan