Extensive deletions and insertions in different MHC supratypes detected by pusled field gel electrophoresis

Extensive deletions and insertions in different MHC supratypes detected by pusled field gel electrophoresis
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通过脉冲场凝胶电泳检测到不同 MHC 超型中的广泛缺失和插入

DOI:
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发表时间:
1988
影响因子:
15.3
通讯作者:
R. L. Dawkins
R. L. Dawkins
中科院分区:
医学1区
文献类型:
--
作者:
K. Tokunaga;G. Saueracker;P H Kay;F. Christiansen;R. Anand;R. L. Dawkins

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在用低频切割限制性内切酶消化基因组 DNA 后,使用脉冲场电泳 (PFGE) 在六种不同超型的多个示例中检查了人类 MHC 的基因组组织。限制性片段长度和条带强度的差异对于每种超型而言是特异的。 MHC 作图表明,每种超型在 HLA B 和 DQ 区域之间都包含先前未描述的缺失和插入。
The genomic organization of the human MHC was examined in multiple examples of six different supratypes using pulsed field electrophoresis (PFGE) after digestion of genomic DNA with infrequency cutting restriction endonucleases. Differences in restriction fragment length and band intensity were shown to be specific for each supratype. Mapping of the MHC revealed that each supratype contains previously undescribed deletions and insertions between HLA B and DQ regions.
DOI: 10.1073/pnas.83.14.5111
发表时间: 1986-07-01
影响因子: 11.1
作者:
WHITE, PC;NEW, MI;DUPONT, B
通讯作者: DUPONT, B
DOI: 10.1073/pnas.84.23.8535
发表时间: 1987-12-01
影响因子: 11.1
作者:
CARROLL, MC;KATZMAN, P;SPIES, T
通讯作者: SPIES, T