TVL1-IMPT: Optimization of Peak-to-Valley Dose Ratio Via Joint Total-Variation and L1 Dose Regularization for Spatially Fractionated Pencil-Beam-Scanning Proton Therapy.
TVL1-IMPT: Optimization of Peak-to-Valley Dose Ratio Via Joint Total-Variation and L1 Dose Regularization for Spatially Fractionated Pencil-Beam-Scanning Proton Therapy.
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DOI：
10.1016/j.ijrobp.2022.09.064
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发表时间：
2023-03-01
影响因子：
7
通讯作者：
Gao, Hao
中科院分区：
文献类型：
--
作者：
Zhang, Weijie;Li, Wangyao;Lin, Yuting;Wang, Fen;Chen, Ronald C.;Gao, Hao
质子微束放射治疗（pMBRT）是一种新型的质子空间分割放射治疗（SFRT）。pMBRT可通过高峰谷剂量比（PVDR）的生物剂量节省来降低正常组织的辐射损伤。这项工作将开发一种新的空间分割IMPT治疗计划方法，共同优化计划质量和最大限度地提高PVDR的pMBRT。新的优化方法同时最大化正常组织的PVDR和优化剂量分布在肿瘤靶点和器官的风险（OAR）。PVDR最大化是通过相对于正常组织剂量的联合全变差（TV）和L1正则化。也就是说，在每个射束角度的几个深度的射束-眼-视图投影剂量切片处，剂量的TV最大化，对应于PVDR最大化，而剂量的L1最小化，对应于OAR剂量的最小化和存活分数（SF）的最大化。新的IMPT方法与TV和L1正则化（TVL 1）进行了验证，与传统的IMPT方法（CONV）的pMBRT在几个临床病例的比较。结果表明，TVL 1提供了比CONV更大的PVDR和SF，用于正常组织的生物保护，在物理剂量分布方面保留了计划质量。一种新的空间分割IMPT治疗计划方法的pMBRT，可以优化和改善正常组织PVDR和SF，通过将TV和L1剂量正则化与适当选择的正则化参数IMPT。
Proton minibeam radiation therapy (pMBRT) is a novel proton modality of spatially fractionated RT (SFRT). pMBRT can reduce the radiation damage to normal tissues via biological dose sparing of high peak-to-valley dose ratio (PVDR). This work will develop a new spatially fractionated IMPT treatment planning method for pMBRT that jointly optimizes the plan quality and maximizes the PVDR. The new optimization method simultaneously maximizes the normal-tissue PVDR and optimizes the dose distribution at tumor targets and organs-at-risk (OAR). The PVDR maximization is through the joint total variation (TV) and L1 regularization with respect to the normal-tissue dose. That is, at beam-eye-view projected dose slices of several depths for each beam angle, the TV of dose is maximized, corresponding to the PVDR maximization, while the L1 of dose is minimized, corresponding to the minimization of the OAR dose and maximization of survival fraction (SF). The new IMPT method with TV and L1 regularization (TVL1) was validated in comparison with the conventional IMPT method (CONV) for pMBRT on several clinical cases. The results show that TVL1 provided larger PVDR and SF than CONV for biological sparing of normal tissues, with preserved plan quality in terms of physical dose distribution. A new spatially fractionated IMPT treatment planning method is developed for pMBRT that can optimize and improve normal-tissue PVDR and SF, by incorporating TV and L1 dose regularization with properly chosen regularization parameters into IMPT.
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影响因子：
3.8
作者：
Gao, Hao;Lin, Bowen;Bradley, Jeffery
通讯作者：
Bradley, Jeffery
DOI：
10.1016/0360-3016(82)90459-x
发表时间：
1982-01-01
影响因子：
7
作者：
BARENDSEN, GW
通讯作者：
BARENDSEN, GW
影响因子：
3.3
作者：
Grams, Michael P.;Owen, Dawn;Ma, Daniel J.
通讯作者：
Ma, Daniel J.
影响因子：
3.8
作者：
Howard, Michelle;Beltran, Chris;Herman, Michael G.
通讯作者：
Herman, Michael G.
影响因子：
3.8
作者：
Peucelle, C.;Nauraye, C.;Prezado, Y.
通讯作者：
Prezado, Y.