Cochlear Microphonic and Summating Potential Responses from Click-Evoked Auditory Brain Stem Responses in High-Risk and Normal Infants.
Cochlear Microphonic and Summating Potential Responses from Click-Evoked Auditory Brain Stem Responses in High-Risk and Normal Infants.
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DOI：
10.3766/jaaa.17085
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发表时间：
2018-05
影响因子：
1.2
通讯作者：
Baroch K
中科院分区：
文献类型：
--
作者：
Hunter LL;Blankenship CM;Gunter RG;Keefe DH;Feeney MP;Brown DK;Baroch K
新生儿重症监护病房(NICU)中高胆红素血症发生率高，易患听神经病(AN)的患儿，需要进行耳蜗神经和神经电位检查，以评估其感觉和神经状态。这项研究的目的是确定在短声诱发ABR中常用的记录参数对于记录AN风险婴儿的CM和波I是否有用。具体地说，我们分析了耳蜗微音器(CM)、总和电位(SP)以及波I、III和V。总体目的是比较NICU中接受护理的婴儿和通过新生儿听力筛查的婴儿托儿所(WBN)中的婴儿的诱发反应的潜伏期和幅度。对通过ABR新生儿听力筛查的婴儿进行前瞻性研究，根据他们的出生史(WBN和NICU)进行分组。所有婴儿在大约1个月大时进行诊断ABR测试时，听力状况正常，校正了早产儿。30例(53耳)来自WBN(平均矫正年龄5.0周)和32例(59耳)来自NICU(平均矫正年龄5.7周)听力正常。此外，还包括两名婴儿作为对比病例研究，一名婴儿被诊断为AN，另一名婴儿被诊断为双侧感音神经性听力损失(SNHL)。记录诊断性ABR，包括短声和短声、空气和骨传导刺激。测量波峰I、III、V、SP和CM的潜伏期和波幅，以确定WBN和NICU婴儿的ABR和ECochG变量是否有差异。WBN组和NICU组的ABR波幅和潜伏期无显著差异。NICU组的大多数(75%)有高胆红素血症，但总的来说，当他们在校正年龄约1个月时测试时，他们的ECochG或ABR反应没有显示出影响的证据。这些数据可以作为NICU和正常婴儿在1个月校正年龄时ECochG和ABR潜伏期的标准样本。两个婴儿病例研究，一个被诊断为AN，另一个被诊断为SNHL，证明了在个别病例中使用ECochG和耳声发射来评估AN的风险的复杂性。在Well和NICU的婴儿中，使用标准的点击刺激可以很容易地测量耳蜗微音器和总和的电位。潜伏期和波幅的标准范围对解释ECochG和ABR成分很有用。在包括耳声发射和声反射测试的测试电池中包括ECochG和ABR测试，可能会对婴儿AN和SNHL的风险提供更精确的评估。
Examination of cochlear and neural potentials is necessary to assess sensory and neural status in infants, especially those cared for in neonatal intensive care units (NICU) who have high rates of hyperbilirubinemia and thus are at risk for auditory neuropathy (AN). The purpose of this study was to determine whether recording parameters commonly used in click-evoked ABR are useful for recording CM and Wave I in infants at risk for AN. Specifically, we analyzed cochlear microphonic (CM), summating potential (SP) and Waves I, III and V. The overall aim was to compare latencies and amplitudes of evoked responses in infants cared for in NICUs with infants in a well-baby nursery (WBN), both of which passed newborn hearing screening. Prospective study of infants that passed ABR newborn hearing screening were grouped based on their birth history (WBN and NICU). All infants had normal hearing status when tested with diagnostic ABR at about 1 month of age, corrected for prematurity. Thirty infants (53 ears) from the WBN (mean corrected age at test = 5.0 weeks) and thirty-two infants (59 ears) from the NICU (mean corrected age at test = 5.7 weeks) with normal hearing were included in this study. In addition, two infants were included as comparative case studies, one that was diagnosed with AN, and another case that was diagnosed with bilateral sensorineural hearing loss (SNHL). Diagnostic ABR including click and tone burst air and bone conduction stimuli were recorded. Peak Waves I, III and V, SP and CM latency and amplitude (peak to trough) were measured to determine if there were differences in ABR and ECochG variables between WBN and NICU infants. No significant group differences were found between WBN and NICU groups for ABR waveforms, CM or SP, including amplitude and latency values. The majority (75%) of the NICU group had hyperbilirubinemia, but overall they did not show evidence of effects in their ECochG or ABR responses when tested at about 1 month corrected age. These data may serve as a normative sample for NICU and well infant ECochG and ABR latencies at 1 month corrected age. Two infant case studies, one diagnosed with AN and another with SNHL demonstrated the complexity of using ECochG and otoacoustic emissions to assess the risk of AN in individual cases. Cochlear microphonic and summating potentials can be readily measured using standard click stimuli in both well and NICU infants. Normative ranges for latency and amplitude are useful for interpreting ECochG and ABR components. Inclusion of ECochG and ABR tests in a test battery that also includes otoacoustic emission and acoustic reflex tests may provide a more refined assessment of the risks of AN and SNHL in infants.
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影响因子：
1.2
作者：
Berlin, Charles I;Hood, Linda J;Thibodaux, Melanie
通讯作者：
Thibodaux, Melanie
影响因子：
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作者：
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作者：
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通讯作者：
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作者：
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通讯作者：
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影响因子：
4.7
作者：
Santarelli, Rosamaria;Starr, Arnold;Arslan, Edoardo
通讯作者：
Arslan, Edoardo