Clarification of the Innervation of the Bladder, External Urethral Sphincter and Clitoris: A Neuronal Tracing Study in Female Mongrel Hound Dogs.
Clarification of the Innervation of the Bladder, External Urethral Sphincter and Clitoris: A Neuronal Tracing Study in Female Mongrel Hound Dogs.
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DOI：
10.1002/ar.23808
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Ruggieri MR
中科院分区：
文献类型：
--
作者：
Barbe MF;Gomez-Amaya SM;Salvadeo DM;Lamarre NS;Tiwari E;Cook S;Glair CP;Jang DH;Ragheb RM;Sheth A;Braverman AS;Ruggieri MR
许多研究泌尿生殖系统结构的神经支配集中在传入或传出输入，或仅在系统的一个结构。我们的目的是澄清神经支配的膀胱，尿道外括约肌（EUS）和阴蒂。将逆行染料注射到雌性犬的每个终末器官中。检查脊髓、膀胱中段、脊髓、肠系膜尾侧、交感干和盆丛神经节的逆行染料标记神经元。膀胱逆行标记的神经元主要分布于L7-S2脊神经节、S1-S3脊髓外侧正中神经节、肠系膜尾侧神经节、T11-L2和L 6-S2交感干神经节以及盆丛神经节。膀胱中壁含有许多壁内神经节神经元标记顺行骨盆神经，和壁内神经节逆行标记周围输尿管口的染料标记网站。从阴蒂逆行标记的神经元仅见于L7和S1脊神经节、L7-S3脊髓外侧正中神经节、S1交感干神经节和肠系膜尾侧神经节。EUS逆行标记的神经元主要位于S1和S2脊神经节、S1-S3的脊髓IX板、肠系膜尾神经节和S1-S2交感干神经节。因此，从脊髓到每个终末器官的直接输入被确定，以及涉及几个神经节的多突触回路，包括膀胱壁中的壁内神经节。了解这一复杂的传入和传出输入到泌尿生殖系统结构的回路，对于了解和治疗泌尿生殖系统功能障碍是必要的。
Many studies examining the innervation of genitourinary structures focus on either afferent or efferent inputs, or on only one structure of the system. We aimed to clarify innervation of the bladder, external urethral sphincter (EUS) and clitoris. Retrograde dyes were injected into each end organ in female dogs. Spinal cord, mid-bladder, and spinal, caudal mesenteric, sympathetic trunk and pelvic plexus ganglia were examined for retrograde dye-labeled neurons. Neurons retrogradely labeled from the bladder were found primarily in L7-S2 spinal ganglia, spinal cord lateral zona intermedia at S1-S3 levels, caudal mesenteric ganglia, T11-L2 and L6-S2 sympathetic trunk ganglia, and pelvic plexus ganglia. The mid-bladder wall contained many intramural ganglia neurons labeled anterogradely from the pelvic nerve, and intramural ganglia retrogradely labeled from dye labeling sites surrounding ureteral orifices. Neurons retrogradely labeled from the clitoris were found only in L7 and S1 spinal ganglia, L7-S3 spinal cord lateral zona intermedia, and S1 sympathetic trunk ganglia, and caudal mesenteric ganglia. Neurons retrogradely labeled from the EUS were found in primarily at S1 and S2 spinal ganglia, spinal cord lamina IX at S1-S3, caudal mesenteric ganglia, and S1-S2 sympathetic trunk ganglia. Thus, direct inputs from the spinal cord to each end organ were identified, as well as multisynaptic circuits involving several ganglia, including intramural ganglia in the bladder wall. Knowledge of this complex circuitry of afferent and efferent inputs to genitourinary structures is necessary to understand and treat genitourinary dysfunction.
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DOI：
10.1002/ar.20962
发表时间：
2009-11-01
影响因子：
2
作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
1986-04-01
期刊：
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
影响因子：
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作者：
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通讯作者：
BURNSTOCK, G
DOI：
10.1016/0165-1838(82)90070-4
发表时间：
1982-01-01
期刊：
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
影响因子：
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ELFVIN, LG
DOI：
10.3171/2012.7.spine12214
发表时间：
2012-10
期刊：
Journal of neurosurgery. Spine
影响因子：
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作者：
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通讯作者：
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