Acidic and Hypoxic Microenvironment in Melanoma: Impact of Tumour Exosomes on Disease Progression.
Acidic and Hypoxic Microenvironment in Melanoma: Impact of Tumour Exosomes on Disease Progression.
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DOI：
10.3390/cells10123311
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发表时间：
2021-11-25
期刊：
影响因子：
6
通讯作者：
Parolini I
中科院分区：
文献类型：
--
作者：
Boussadia Z;Gambardella AR;Mattei F;Parolini I
黑色素瘤进展的机制在过去十年中得到了广泛的研究，尽管诊断和治疗取得了进展，但恶性黑色素瘤仍然占皮肤癌死亡的60%。因此，研究工作需要更好地定义黑色素瘤发展的细胞间分子步骤。为了代表肿瘤微环境（TME）的复杂性，我们在这里分析了酸性和缺氧微环境中黑色素瘤的研究以及与基质细胞和免疫细胞的相互作用。在TME内，酸性和缺氧迫使黑色素瘤细胞通过肿瘤周围基质细胞的合作和逃避免疫监视而适应并演变成恶性表型。肿瘤外泌体在细胞间串扰中的作用已得到普遍关注，但在酸性和缺氧条件下的研究较少。因此，本文旨在总结酸性和缺氧微环境在黑色素瘤生物学中的作用，以及黑色素瘤衍生的外泌体（Mexo）在这些条件下所发挥的作用。我们还对酸性和缺氧外泌体的特征进行了展望，以揭示分子，进一步被认为是早期检测疾病的有希望的生物标志物。还将提供和讨论外泌体在黑色素瘤诊断、预后和治疗反应中的使用的最新情况。
The mechanisms of melanoma progression have been extensively studied in the last decade, and despite the diagnostic and therapeutic advancements pursued, malignant melanoma still accounts for 60% of skin cancer deaths. Therefore, research efforts are required to better define the intercellular molecular steps underlying the melanoma development. In an attempt to represent the complexity of the tumour microenvironment (TME), here we analysed the studies on melanoma in acidic and hypoxic microenvironments and the interactions with stromal and immune cells. Within TME, acidity and hypoxia force melanoma cells to adapt and to evolve into a malignant phenotype, through the cooperation of the tumour-surrounding stromal cells and the escape from the immune surveillance. The role of tumour exosomes in the intercellular crosstalk has been generally addressed, but less studied in acidic and hypoxic conditions. Thus, this review aims to summarize the role of acidic and hypoxic microenvironment in melanoma biology, as well as the role played by melanoma-derived exosomes (Mexo) under these conditions. We also present a perspective on the characteristics of acidic and hypoxic exosomes to disclose molecules, to be further considered as promising biomarkers for an early detection of the disease. An update on the use of exosomes in melanoma diagnosis, prognosis and response to treatment will be also provided and discussed.
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影响因子：
3.7
作者：
Balgi AD;Diering GH;Donohue E;Lam KK;Fonseca BD;Zimmerman C;Numata M;Roberge M
通讯作者：
Roberge M
DOI：
10.1186/s13046-021-01926-6
发表时间：
2021-05-08
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
D'Aguanno S;Mallone F;Marenco M;Del Bufalo D;Moramarco A
通讯作者：
Moramarco A
影响因子：
4.6
作者：
de Sousa Andrade, Luciana Nogueira;Otake, Andreia Hanada;Chammas, Roger
通讯作者：
Chammas, Roger
微环境酸度和肿瘤外泌体在癌症免疫调节中的作用。
影响因子：
0.9
作者：
Boussadia Z;Zanetti C;Parolini I
通讯作者：
Parolini I
影响因子：
5.5
作者：
Dong Q;Liu X;Cheng K;Sheng J;Kong J;Liu T
通讯作者：
Liu T