Phospholipid polymer hydrogel formed by the photodimerization of cinnamoyl groups in the polymer side chain
Phospholipid polymer hydrogel formed by the photodimerization of cinnamoyl groups in the polymer side chain
复制标题
聚合物侧链肉桂酰基光二聚形成的磷脂聚合物水凝胶
DOI：
10.1002/app.24176
复制
发表时间：
2007
影响因子：
3
通讯作者：
K. Ishihara
中科院分区：
文献类型：
--
作者：
Junichiro Yamaguchi;J. Watanabe;M. Takai;K. Ishihara
通过甲基丙烯酸4-（4-甲氧基肉桂酰基）苯酯和2-甲基丙烯酰氧乙基磷酰胆碱的无规共聚，合成了具有光交联性和生物相容性的新型聚合物。这些聚合物用作预聚物以通过光照射制备水凝胶。光照射5 s后，甘精胰岛素开始升高，360 s后达到平衡状态。肉桂酰基在347 nm处的最大吸收随光照时间的延长而消失。也就是说，聚合物中肉桂酰基之间的二聚反应进行并形成水凝胶。水凝胶的平衡水浓度大于90%。此外，我们成功地通过光掩模的光照射在玻璃上制备了微形状的水凝胶。将光掩模的窗口形状转移到形成的水凝胶上。我们的结论是，这些可光交联聚合物可以在制备用于分离或固定生物分子和细胞的微流控装置中使用。© 2007 Wiley Periodicals，Inc.应用聚合物科学杂志104：44-50，2007
We synthesized new polymers with both photocrosslinkability and biocompatibility by a random copolymerization of 4-(4-methoxycinnamoyl)phenyl methacrylate and 2-methacryloyloxyethyl phosphorylcholine. These polymers were used as prepolymers to make a hydrogel by photoirradiation. Gelation began with 5 s of photoirradiation and reached an equilibrium state after 360 s of photoirradiation. The absorption maximum at 347 nm, attributed to the cinnamoyl group, disappeared with the photoirradiation time. That is, dimerization between cinnamoyl groups in the polymer proceeded and formed a hydrogel. The equilibrium water concentration of the hydrogels was more than 90%. Moreover, we succeeded in making a microshape hydrogel on glass by photoirradiation through a photomask. The window shape of the photomask was transferred to the hydrogel that was formed. We concluded that these photocrosslinkable polymers could be useful in preparing microfluidic devices for separating or immobilizing biomolecules and cells. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 104: 44–50, 2007
DOI：
10.1002/jbm.820251107
发表时间：
1991-11-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
ISHIHARA, K;ZIATS, NP;ANDERSON, JM
通讯作者：
ANDERSON, JM