Advances in rheumatoid arthritis animal models.
Advances in rheumatoid arthritis animal models.
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DOI：
10.1007/s11926-011-0200-z
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发表时间：
2011-10
影响因子：
5
通讯作者：
Brahn, Ernest
中科院分区：
文献类型：
--
作者：
Moudgil, Kamal D.;Kim, Peter;Brahn, Ernest
关键词：
Rheumatoid arthritis (RA)Animal modelsCollagen-induced arthritis (CIA)Adjuvant arthritis (AA)Glucose-6-phosphate isomerase (GPI)Proteoglycan-induced arthritis (PGIA)CytokinesInterleukinTumor necrosis factor-alpha (TNF-alpha)Interferon-gamma (IFN-gamma)CD4+CD25+regulatory T cells (Treg)Dendritic cells (DC)InflammationReceptor activator of nuclear factor-kappa B ligand (RANKL)Osteoprotegerin (OPG)ChemokinesDevelopmental endothelial locus-1 (Del-1)Anticyclic citrullinated peptide (aCCP) antibodyalpha 7-nicotinic acetylcholine receptors (alpha 7nAChRs)Sphingosine-1-phosphate (S1P)Spleen tyrosine kinase (Syk)Janus kinase (JAK)-Interleukin-1 receptor antagonist (IL-1Ra)
类风湿性关节炎（RA）的实验模型极大地促进了我们对这种使人衰弱的自身免疫性疾病的发病机制和治疗的理解。在过去几年中，在确定新细胞因子和调节性T细胞的作用、炎症介导的骨和软骨损伤以及胆碱能抗炎途径在调节关节炎疾病过程中的作用方面取得了重大进展。此外，新的治疗靶点，包括特定的酪氨酸激酶和蛋白酶体亚基已经被探索。这些进展为RA管理的持续改善提供了新的乐观。
Experimental models of rheumatoid arthritis (RA) have contributed immensely to our understanding of the pathogenesis as well as the treatment of this debilitating autoimmune disease. Significant progress has been made in the past few years in defining the role of newer cytokines and regulatory T cells, of inflammation-mediated bone and cartilage damage, and of the cholinergic anti-inflammatory pathway in modulating the disease process in arthritis. Furthermore, new therapeutic targets, including specific tyrosine kinases and proteasome subunits have been explored. These advances offer renewed optimism for continued improvements in the management of RA.
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影响因子：
4.6
作者：
Ablin, J. N.;Entin-Meer, M.;Barshack, I.
通讯作者：
Barshack, I.
影响因子：
4.9
作者：
Adamopoulos IE;Chao CC;Geissler R;Laface D;Blumenschein W;Iwakura Y;McClanahan T;Bowman EP
通讯作者：
Bowman EP
DOI：
10.4049/jimmunol.0902907
发表时间：
2010-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Doodes PD;Cao Y;Hamel KM;Wang Y;Rodeghero RL;Mikecz K;Glant TT;Iwakura Y;Finnegan A
通讯作者：
Finnegan A
影响因子：
8.6
作者：
Kim, Eugene Y.;Chi, Howard H.;Moudgil, Kama D.
通讯作者：
Moudgil, Kama D.
影响因子：
4.4
作者：
Connolly, Mary;Marrelli, Alessandra;Fearon, Ursula
通讯作者：
Fearon, Ursula