Cadmium exposure and cancer mortality in the Third National Health and Nutrition Examination Survey cohort.
Cadmium exposure and cancer mortality in the Third National Health and Nutrition Examination Survey cohort.
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DOI：
10.1136/oemed-2011-100111
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发表时间：
2012-02
影响因子：
4.9
通讯作者：
Newcomb PA
中科院分区：
文献类型：
--
作者：
Adams SV;Passarelli MN;Newcomb PA
这项研究检查了第三次全国健康和营养检查调查(NHANES III)队列中的前瞻性数据，以调查普通人群中镉暴露与癌症死亡率以及与镉暴露相关的特定癌症的关系。国家卫生统计中心获得了NHANES III参与者截至2006年12月31日的生命状况和死因。测量现场尿样的镉浓度，并对尿肌酐进行校正。以年龄为时间指标的加权COX比例风险回归被用来估计美国所有癌症和导致死亡最多的癌症与UCD相关的死亡率的性别调整风险比(AHRS)。估计是根据吸烟史和调整后的教育程度、体重指数和种族进行分层的。UCD与癌症死亡率相关(每两倍UCD的AHR(95%CI)，男性：1.26(1.07-1.48)；女性：1.21(1.04-1.42))。在男性中，肺癌、胰腺癌和非霍奇金淋巴瘤的死亡率与UCD有关；提示与白血病死亡率有关。在女性中，被认为与肺癌、白血病、卵巢癌和子宫癌的死亡率有关，但证据比男性更弱。镉似乎与男性和女性的总体癌症死亡率有关，但相关的具体癌症在男性和女性之间有所不同，这为未来的研究提供了途径。这项研究的局限性包括吸烟或其他因素造成不受控制的混淆的可能性，以及因某些癌症而死亡的有限数量。
This study examined prospective data from the Third National Health and Nutrition Examination Survey (NHANES III) cohort to investigate the relationship between cadmium exposure and cancer mortality, and the specific cancers associated with cadmium exposure, in the general population. Vital status and cause of death through December 31, 2006 were obtained by the National Center for Health Statistics for NHANES III participants. Cadmium concentration of spot urine samples was measured, and corrected for urine creatinine. Weighted Cox proportional hazards regression with age as the time metric was applied to estimate sex-specific adjusted hazard ratios (aHRs) of mortality associated with uCd for all cancers and the cancers responsible for the most deaths in the US. Estimates were stratified by smoking history and adjusted education, body mass index, and race. uCd was associated with cancer mortality (aHR per 2-fold higher uCd (95%CI), men: 1.26 (1.07–1.48)); women: 1.21 (1.04–1.42)). In men, mortality from lung, pancreatic cancer and non-Hodgkin lymphoma was associated with uCd; an association with leukemia mortality was suggested. In women, associations were suggested with mortality due to lung cancer, leukemia, ovarian, and uterine cancer, but evidence was weaker than in men. Cadmium appears to be associated with overall cancer mortality in men and women, but the specific cancers associated differ between men and women, suggesting avenues for future research. Limitations of the study include the possibility of uncontrolled confounding by cigarette smoking or other factors, and the limited number of deaths due to some cancers.
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影响因子：
6.4
作者：
Vrieling, Alina;Bueno-de-Mesquita, H. Bas;Riboli, Elio
通讯作者：
Riboli, Elio
影响因子：
10.4
作者：
Menke A;Muntner P;Silbergeld EK;Platz EA;Guallar E
通讯作者：
Guallar E
影响因子：
82.9
作者：
Johnson, MD;Kenney, N;Martin, MB
通讯作者：
Martin, MB
影响因子：
51.1
作者：
Nawrot, T;Plusquin, M;Staessen, JA
通讯作者：
Staessen, JA
影响因子：
10.4
作者：
KJELLSTROM, T
通讯作者：
KJELLSTROM, T