IL-15 and N-803 for HIV Cure Approaches.
IL-15 and N-803 for HIV Cure Approaches.
复制标题
DOI：
10.3390/v15091912
复制
发表时间：
2023-09-12
期刊：
影响因子：
--
通讯作者：
Bosque A
中科院分区：
文献类型：
--
作者：
Howard JN;Bosque A
In spite of the advances in antiretroviral therapy to treat HIV infection, the presence of a latent reservoir of HIV-infected cells represents the largest barrier towards finding a cure. Among the different strategies being pursued to eliminate or reduce this latent reservoir, the γc-cytokine IL-15 or its superagonist N-803 are currently under clinical investigation, either alone or with other interventions. They have been shown to reactivate latent HIV and enhance immune effector function, both of which are potentially required for effective reduction of latent reservoirs. In here, we present a comprehensive literature review of the different in vitro, ex vivo, and in vivo studies conducted to date that are aimed at targeting HIV reservoirs using IL-15 and N-803.
登录
查看更多内容
影响因子：
8.8
作者：
Bosque A;Nilson KA;Macedo AB;Spivak AM;Archin NM;Van Wagoner RM;Martins LJ;Novis CL;Szaniawski MA;Ireland CM;Margolis DM;Price DH;Planelles V
通讯作者：
Planelles V
DOI：
10.1073/pnas.94.24.13193
发表时间：
1997-11-25
影响因子：
11.1
作者：
Chun, TW;Stuyver, L;Fauci, AS
通讯作者：
Fauci, AS
影响因子：
32.4
作者：
Babon JJ;Kershaw NJ;Murphy JM;Varghese LN;Laktyushin A;Young SN;Lucet IS;Norton RS;Nicola NA
通讯作者：
Nicola NA
影响因子：
11.8
作者：
Cheng, A;Uetani, N;Tremblay, ML
通讯作者：
Tremblay, ML
影响因子：
6.4
作者：
Crooks, Amanda M.;Bateson, Rosalie;Archin, Nancie M.
通讯作者：
Archin, Nancie M.