The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases.
The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases.
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肠道微生物胆汁酸轴将慢性失眠与心脏代谢疾病之间的正相关联系起来
DOI：
10.1038/s41467-022-30712-x
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发表时间：
2022-05-30
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
来自人类队列的证据表明，慢性失眠与心脏代谢疾病（CMD）的高风险相关，但肠道微生物群是否起作用尚不清楚。在一项纵向队列研究中（n = 1809），我们发现肠道微生物群-胆酸轴可能与慢性失眠和CMD之间的正相关。Ruminococcaceae UCG-002和Ruminococcaceae UCG-003是介导慢性失眠与CMD正相关的主要属。在一个独立的横断面队列（n = 6122）中也观察到了这些结果。这些肠道微生物标志物与CMD之间的负相关是由某些胆汁酸（异胆酸、小胆酸和非胆酸）介导的。与慢性失眠症相比，习惯性饮茶与肠道微生物群和胆汁酸的关系可能相反。我们的工作表明，微生物-胆酸轴可能是减少慢性失眠对心脏代谢健康影响的潜在干预目标。慢性失眠与心脏代谢疾病有关。在这里，在两个临床队列中（n = 7931），作者表明肠道微生物-胆酸轴可能是减轻慢性失眠对心脏代谢健康影响的干预目标。
Evidence from human cohorts indicates that chronic insomnia is associated with higher risk of cardiometabolic diseases (CMD), yet whether gut microbiota plays a role is unclear. Here, in a longitudinal cohort (n = 1809), we find that the gut microbiota-bile acid axis may link the positive association between chronic insomnia and CMD. Ruminococcaceae UCG-002 and Ruminococcaceae UCG-003 are the main genera mediating the positive association between chronic insomnia and CMD. These results are also observed in an independent cross-sectional cohort (n = 6122). The inverse associations between those gut microbial biomarkers and CMD are mediated by certain bile acids (isolithocholic acid, muro cholic acid and nor cholic acid). Habitual tea consumption is prospectively associated with the identified gut microbiota and bile acids in an opposite direction compared with chronic insomnia. Our work suggests that microbiota-bile acid axis may be a potential intervention target for reducing the impact of chronic insomnia on cardiometabolic health. Chronic insomnia is associated with cardiometabolic diseases. Here, in two clinical cohorts (n = 7,931), authors show that gut microbiota-bile acid axis may be an intervention target to attenuate the impact of chronic insomnia on cardiometabolic health.
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