The gene balance hypothesis: implications for gene regulation, quantitative traits and evolution.
The gene balance hypothesis: implications for gene regulation, quantitative traits and evolution.
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DOI:
10.1111/j.1469-8137.2009.03087.x
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发表时间:
2010-04
期刊:
影响因子:
--
通讯作者:
Veitia RA
中科院分区:
文献类型:
--
作者:
Birchler JA;Veitia RA
The Gene Balance Hypothesis states that the stoichoimetry of members of multi-subunit complexes affects the function of the whole due to the kinetics and mode of assembly. Gene regulatory mechanisms would be governed by these principles. Here, we review the impact of this concept with regard to the effects on the genetics of quantitative traits, the fate of duplication of genes following polyploidization events or segmental duplication, the basis of aneuploid syndromes, the constraints on cis and trans variation in gene regulation and the potential involvement in hybrid incompatibilities.
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