The rs2147578 C > G polymorphism in the Inc-LAMC2-1:1 gene is associated with increased neuroblastoma risk in the Henan children.
The rs2147578 C > G polymorphism in the Inc-LAMC2-1:1 gene is associated with increased neuroblastoma risk in the Henan children.
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DOI：
10.1186/s12885-018-4847-y
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发表时间：
2018-10-03
期刊：
影响因子：
3.8
通讯作者：
Zou Y
中科院分区：
文献类型：
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作者：
Yang T;Zhang Z;Zhang J;Tan T;Yang J;Pan J;Hu C;Li J;Xia H;He J;Zou Y
长链非编码RNA基因Lnc-LAMC 2 -1：1中的rs 2147578 C > G多态性与对几种癌症的易感性增加相关。然而，其在神经母细胞瘤中的作用尚未得到评估。我们研究了lnc-LAMC 2 -1：1 rs 2147578 C > G多态性与中国汉族人群神经母细胞瘤易感性之间的关系。共收集了来自河南和广东的393例神经母细胞瘤患者和812名健康个体，并进行了基因分型。比值比（OR）和95%置信区间（CI）用于确定相关性的强度。联合分析显示lnc-LAMC 2 -1：1 rs 2147578 C > G多态性与神经母细胞瘤易感性增加相关（CG vs. CC：校正OR = 1.33，95%CI = 1.01-1.75，P = 0.045; CG/GG vs. CC：校正OR = 1.34，95%CI = 1.03-1.74，P = 0.028）。分层分析显示，rs 2147578 CG/GG基因型的18个月以下儿童患神经母细胞瘤的风险增加（校正OR = 1.70，95%CI = 1.08-2.67，P = 0.022）。携带rs 2147578 CG/GG基因型的女性也增加了神经母细胞瘤的易感性（校正OR = 2.08，95%CI = 1.37-3.18，P = 0.0007）。此外，lnc-LAMC 2 -1：1 rs 2147578 CG/GG基因型儿童更易发生早期神经母细胞瘤（校正OR = 1.46，95%CI = 1.01-2.12，P = 0.046）。Lnc-LAMC 2 -1：1 rs 2147578 C > G多态性可能与河南省儿童神经母细胞瘤易感性增加有关。本文的在线版本（10.1186/s12885-018-4847-y）包含补充材料，可供授权用户使用。
The rs2147578 C > G polymorphism in the long non-coding RNA gene Lnc-LAMC2–1:1 is associated with increased susceptibility to a few types of cancers. However, its role in neuroblastoma has not been evaluated yet. We investigated the association between the lnc-LAMC2–1:1 rs2147578 C > G polymorphism and neuroblastoma susceptibility in Chinese Han populations. A total of 393 neuroblastoma cases and 812 healthy individuals from the Henan and Guangdong provinces were enrolled and subjected to genotyping. Odds ratio (OR) and 95% confidence interval (CI) were used to determine the strength of the association of interest. Combined analysis revealed that the lnc-LAMC2–1:1 rs2147578 C > G polymorphism was associated with increased neuroblastoma susceptibility (CG vs. CC: adjusted OR = 1.33, 95% CI = 1.01–1.75, P = 0.045; CG/GG vs. CC: adjusted OR = 1.34, 95% CI = 1.03–1.74, P = 0.028). In stratification analysis, children under 18 months with rs2147578 CG/GG genotypes had an increased neuroblastoma risk (adjusted OR = 1.70, 95% CI = 1.08–2.67, P = 0.022). Females with rs2147578 CG/GG genotypes also had increased neuroblastoma susceptibility (adjusted OR = 2.08, 95% CI = 1.37–3.18, P = 0.0007). In addition, children with lnc-LAMC2–1:1 rs2147578 CG/GG genotypes were prone to develop earlier stages of neuroblastoma (adjusted OR = 1.46, 95% CI = 1.01–2.12, P = 0.046). The Lnc-LAMC2–1:1 rs2147578 C > G polymorphism may contribute to increased neuroblastoma susceptibility in children of Henan province. The online version of this article (10.1186/s12885-018-4847-y) contains supplementary material, which is available to authorized users.
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通讯作者：
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