Effect of Ursodeoxycholic Acid on Biliary Bile Acid and Bile Lipid Composition in Gallstone Patients
Effect of Ursodeoxycholic Acid on Biliary Bile Acid and Bile Lipid Composition in Gallstone Patients
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熊去氧胆酸对胆结石患者胆汁胆汁酸和胆汁脂质组成的影响
DOI：
10.1002/hep.1840040119
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发表时间：
1984
期刊：
影响因子：
13.5
通讯作者：
S. Walker
中科院分区：
文献类型：
--
作者：
A. Stiehl;R. Raedsch;G. Rudolph;S. Walker
在5例放射性胆结石患者中，研究了熊去氧胆酸（Urso）每日250、500、750、1，000和1，250 mg剂量对胆汁脂质和胆汁酸组成的影响。500 mg Urso/天（7.1 mg/kg）时胆汁胆固醇从8.8 ± 0.8 mol %降至4.4 ± 0.2 mol %，750 mg Urso/天（10.7 mg/kg）时降至4.2 ± 0.3 mol %。每日给予1，000或1，250 mg Urso未进一步降低胆汁胆固醇。磷脂和总胆汁酸的胆汁含量保持不变。
In five patients with radiolucent gallstones, the effect of ursodeoxycholic acid (Urso) in doses of 250, 500, 750, 1,000, and 1,250 mg per day on biliary lipid and bile acid composition was studied. Biliary cholesterol decreased from 8.8 ± 0.8 mole% to 4.4 ± 0.2 mole% at 500 mg Urso per day (7.1 mg per kg) and to 4.2 ± 0.3 mole% at 750 mg Urso per day (10.7 mg per kg). Administration of 1,000 or 1,250 mg Urso per day produced no further decrease of biliary cholesterol. The biliary content of phospholipids and total bile acids remained unchanged.
7 肠道厌氧菌（真杆菌属 V.P.I.）的全细胞和细胞提取物对熊去氧胆酸进行β-脱羟基作用。
影响因子：
6.5
作者：
White,BA;Fricke,RJ;Hylemon,PB
通讯作者：
Hylemon,PB
影响因子：
39.2
作者：
TINT, GS;SALEN, G;SHEFER, S
通讯作者：
SHEFER, S