Regulation of mRNA Stability During Bacterial Stress Responses.
Regulation of mRNA Stability During Bacterial Stress Responses.
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DOI：
10.3389/fmicb.2020.02111
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发表时间：
2020
影响因子：
5.2
通讯作者：
Shell SS
中科院分区：
文献类型：
--
作者：
Vargas-Blanco DA;Shell SS
细菌具有非凡的感知环境变化的能力，并迅速调节其转录和转录后机制作为一种反应。在导致生长减缓或停止的条件下，细菌通常会稳定其转录组，这已被证明是一种保守的应激反应。近年来，各种各样的研究已经阐明了mRNA降解的许多机制，但对应激条件下mRNA降解的调控的理解仍然难以捉摸。在这篇综述中，我们讨论了影响细菌mRNA稳定性的各种机制。虽然这些机制中的许多是转录特异性的，但它们提供了对全局mRNA稳定的可能机制的见解。为此，我们收集了RNA二级结构如何影响mRNA命运的信息；与核糖体、RNA结合蛋白和小RNA的相互作用；RNA碱基修饰；5 '端的化学性质；rna酶和其他降解蛋白的活性和浓度；mRNA和RNase定位；以及严厉的回应。我们还分析了已报道的mRNA丰度和mRNA稳定性之间的关系，并讨论了应激相关mRNA稳定性作为治疗发展的潜在靶点的重要性。
Bacteria have a remarkable ability to sense environmental changes, swiftly regulating their transcriptional and posttranscriptional machinery as a response. Under conditions that cause growth to slow or stop, bacteria typically stabilize their transcriptomes in what has been shown to be a conserved stress response. In recent years, diverse studies have elucidated many of the mechanisms underlying mRNA degradation, yet an understanding of the regulation of mRNA degradation under stress conditions remains elusive. In this review we discuss the diverse mechanisms that have been shown to affect mRNA stability in bacteria. While many of these mechanisms are transcript-specific, they provide insight into possible mechanisms of global mRNA stabilization. To that end, we have compiled information on how mRNA fate is affected by RNA secondary structures; interaction with ribosomes, RNA binding proteins, and small RNAs; RNA base modifications; the chemical nature of 5′ ends; activity and concentration of RNases and other degradation proteins; mRNA and RNase localization; and the stringent response. We also provide an analysis of reported relationships between mRNA abundance and mRNA stability, and discuss the importance of stress-associated mRNA stabilization as a potential target for therapeutic development.
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影响因子：
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