Argon: systematic review on neuro- and organoprotective properties of an "inert" gas.

Argon: systematic review on neuro- and organoprotective properties of an "inert" gas.
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Argon:“惰性”气体的神经和有机保护特性的系统综述。

DOI:
10.3390/ijms151018175
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发表时间:
2014-10-10
影响因子:
5.6
通讯作者:
Argon Organo-Protective Network (AON)
Argon Organo-Protective Network (AON)
中科院分区:
生物学2区
文献类型:
--
作者:
Höllig A;Schug A;Fahlenkamp AV;Rossaint R;Coburn M;Argon Organo-Protective Network (AON)

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氩属于稀有气体,被认为是化学惰性的。令人惊讶的是,这些气体中的一些发挥生物特性,在过去的几十年里,越来越多的报告表明,神经保护和器官保护作用。最近的研究主要使用在体内或体外模型的缺血性病变,以调查氩治疗的效果。已经发表了关于脑缺血、创伤性脑损伤和缺氧缺血性脑病等病理学的有希望的数据。然而,所应用的模型和治疗气体的给药各不相同。在这里,我们提供了一个系统的审查,总结现有的数据氩的神经和器官保护作用,并讨论其可能的作用机制。我们的目的是提供一个总结,以便在更均匀的环境下进行进一步的研究,以探讨氩气的可能临床应用。
Argon belongs to the group of noble gases, which are regarded as chemically inert. Astonishingly some of these gases exert biological properties and during the last decades more and more reports demonstrated neuroprotective and organoprotective effects. Recent studies predominately use in vivo or in vitro models for ischemic pathologies to investigate the effect of argon treatment. Promising data has been published concerning pathologies like cerebral ischemia, traumatic brain injury and hypoxic ischemic encephalopathy. However, models applied and administration of the therapeutic gas vary. Here we provide a systematic review to summarize the available data on argon’s neuro- and organoprotective effects and discuss its possible mechanism of action. We aim to provide a summary to allow further studies with a more homogeneous setting to investigate possible clinical applications of argon.
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影响因子: 5
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