Screen for New Antimicrobial Natural Products from the NCI Program for Natural Product Discovery Prefractionated Extract Library.
Screen for New Antimicrobial Natural Products from the NCI Program for Natural Product Discovery Prefractionated Extract Library.
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DOI：
10.1021/acsinfecdis.3c00067
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发表时间：
2023-06-09
影响因子：
5.3
通讯作者：
O'Keefe, Barry R.
中科院分区：
文献类型：
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作者：
Martinez-Fructuoso, Lucero;Arends, S. J. Ryan;Freire, Vitor F.;Evans, Jason R.;DeVries, Sean;Peyser, Brian D.;Akee, Rhone K.;Thornburg, Christopher C.;Kumar, Rohitesh;Ensel, Susan;Morgan, Gina M.;McConachie, Grant D.;Veeder, Nathan;Duncan, Leonard R.;Grkovic, Tanja;O'Keefe, Barry R.
关键词：
The continuing emergence of antibiotic-resistant microbes highlights the need for the identification of new chemotypes with antimicrobial activity. One of the most prolific sources of antimicrobial molecules has been the systematic screening of natural product samples. The National Institute of Allergy and Infectious Diseases and the National Cancer Institute here report a large screen of 326,656 partially purified natural product fractions against a panel of four microbial pathogens, resulting in the identification of >3000 fractions with antifungal and/or antibacterial activity. A small sample of these active fractions was further purified and the chemical structures responsible for the antimicrobial activity were elucidated. The proof-of-concept study identified many different chemotypes, several of which have not previously been reported to have antimicrobial activity. The results show that there remain many unidentified antibiotic compounds from nature.
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影响因子：
5.4
作者：
Campos PE;Herbette G;Fougère L;Clerc P;Tintillier F;de Voogd NJ;Le Goff G;Ouazzani J;Gauvin-Bialecki A
通讯作者：
Gauvin-Bialecki A
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影响因子：
5.4
作者：
Guo P;Li G;Liu Y;Lu A;Wang Z;Wang Q
通讯作者：
Wang Q
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DOI：
10.3390/molecules21020150
发表时间：
2016-01-26
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Gong KK;Tang XL;Liu YS;Li PL;Li GQ
通讯作者：
Li GQ
影响因子：
4.2
作者：
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通讯作者：
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影响因子：
9.9
作者：
通讯作者：
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