Imidazole Alkaloids from the South China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral Activities.
Imidazole Alkaloids from the South China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral Activities.
复制标题
南海海绵异针鱼中的咪唑生物碱及其细胞毒和抗病毒活性
DOI：
10.3390/molecules21020150
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发表时间：
2016-01-26
期刊：
影响因子：
--
通讯作者：
Li GQ
中科院分区：
文献类型：
--
作者：
Gong KK;Tang XL;Liu YS;Li PL;Li GQ
海洋海绵仍然是生物碱的丰富来源，具有有趣的生物活性，并且经常表现出独特的结构框架。在当前的研究中，对从南海采集的海洋海绵 Pericharax hetolaphis 进行化学研究，发现了一种新的咪唑生物碱，名为 naamidine J (1) 以及四种已知的生物碱 (2-5)。它们的结构是通过广泛的光谱方法并将其数据与相关已知化合物的数据进行比较来确定的。所有分离物均具有中心 2-氨基咪唑环，在 C4 和 C5 位置的某种组合中被一或两个官能化苄基取代。评估了分离株针对所选 HL-60、HeLa、A549 和 K562 肿瘤细胞系的细胞毒性以及抗 H1N1（流感病毒 (IAV)）活性。化合物1和2对K562细胞系表现出细胞毒性，IC50值分别为11.3和9.4 μM。化合物5表现出弱的抗H1N1（流感病毒，IAV）活性，抑制率为33%。
Marine sponges continue to serve as a rich source of alkaloids possessing interesting biological activities and often exhibiting unique structural frameworks. In the current study, chemical investigation on the marine sponge Pericharax heteroraphis collected from the South China Sea yielded one new imidazole alkaloid named naamidine J (1) along with four known ones (2–5). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related known compounds. All the isolates possessed a central 2-aminoimidazole ring, substituted by one or two functionalized benzyl groups in some combination of the C4 and C5 positions. The cytotoxicities against selected HL-60, HeLa, A549 and K562 tumor cell lines and anti-H1N1 (Influenza a virus (IAV)) activity for the isolates were evaluated. Compounds 1 and 2 exhibited cytotoxicities against the K562 cell line with IC50 values of 11.3 and 9.4 μM, respectively. Compound 5 exhibited weak anti-H1N1 (influenza a virus, IAV) activity with an inhibition ratio of 33%.
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