B7-H4 expression is associated with tumor progression and prognosis in patients with osteosarcoma.
B7-H4 expression is associated with tumor progression and prognosis in patients with osteosarcoma.
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DOI：
10.1155/2015/156432
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发表时间：
2015
影响因子：
--
通讯作者：
Ma X
中科院分区：
文献类型：
--
作者：
Dong Q;Ma X
越来越多的证据表明B7-H4与肿瘤的发展和预后有关。然而，B7-H4在人骨肉瘤（OS）中表达的临床意义尚不清楚。本研究的目的是检测B7-H4的表达并探讨其在OS中的作用。免疫组织化学检测OS组织中B7-H4的表达。ELISA法检测血中可溶性B7-H4 （sB7-H4）水平。统计学分析B7-H4表达与临床病理因素及预后的关系。我们的研究结果表明，B7-H4在骨肉瘤组织中的表达明显高于配对正常骨组织（P < 0.001）。OS血清中sB7-H4水平显著高于健康对照组（P = 0.005）。组织中B7-H4高表达及sB7-H4水平与肿瘤分期晚期（P < 0.001, P = 0.017, resp）及远处转移相关（P = 0.034, P = 0.021, resp）。此外，B7-H4高表达或血清sB7-H4水平与总生存率差有显著相关性（P = 0.028, P = 0.005，均有统计学意义）。组织和血清样本B7-H4水平是影响OS患者生存时间的独立因素（P = 0.004, P = 0.041，均有统计学意义）。总之，我们的数据表明，评估组织和血液中B7-H4的表达是预测骨肉瘤进展和预后的有用工具。
Increasing evidences have demonstrated that B7-H4 is associated with tumor development and prognosis. However, the clinical significance of B7-H4 expression in human osteosarcoma (OS) remains unclear. The aim of present study was to examine the B7-H4 expression and to explore its contribution in OS. B7-H4 expression in OS tissues was examined by immunohistochemistry. Soluble B7-H4 (sB7-H4) levels in blood were examined by ELISA. The association of B7-H4 expression with clinicopathological factors or prognosis was statistically analyzed. Our findings demonstrated that B7-H4 expression in OS tissues was significantly higher than those in paired normal bone tissues (P < 0.001). sB7-H4 level in OS serum samples was significantly higher than that in healthy controls (P = 0.005). High B7-H4 expression in tissues and sB7-H4 level were both correlated with advanced tumor stage (P < 0.001, P = 0.017, resp.) and distant metastasis (P = 0.034, P = 0.021, resp.). Additionally, high B7-H4 expression or serum sB7-H4 levels were significantly related to poor overall survival (P = 0.028, P = 0.005, resp.). B7-H4 in tissues and serum samples were an independent factor for affecting the survival time of OS patients (P = 0.004, P = 0.041, resp.). Collectively, our data suggest that the evaluation of B7-H4 expression in tissues and blood is a useful tool for predicting the progression of osteosarcoma and prognosis.
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DOI：
10.1111/igc.0b013e3181ad0fa2
发表时间：
2009-12-01
影响因子：
4.8
作者：
Cheng, Lei;Jiang, Jie;Kong, Beihua
通讯作者：
Kong, Beihua
影响因子：
3.7
作者：
Wang L;Zhang Q;Chen W;Shan B;Ding Y;Zhang G;Cao N;Liu L;Zhang Y
通讯作者：
Zhang Y
DOI：
10.1302/0301-620x.92b11.24706
发表时间：
2010-12-01
影响因子：
--
作者：
Wu, P. -K.;Chen, W. -M.;Chen, T. -H.
通讯作者：
Chen, T. -H.
共刺激分子B7-H1、B7-H3、B7-H4在人胰腺癌中的共表达及其临床意义
影响因子：
4
作者：
Chen Y;Sun J;Zhao H;Zhu D;Zhi Q;Song S;Zhang L;He S;Kuang Y;Zhang Z;Li D
通讯作者：
Li D
血清B7-H4表达是胃癌患者重要的预后指标
影响因子：
3.2
作者：
Shi, Hongbing;Ji, Mei;Jiang, Jingting
通讯作者：
Jiang, Jingting