Abandoned prairie vole mothers show normal maternal care but altered emotionality: Potential influence of the brain corticotropin-releasing factor system.
Abandoned prairie vole mothers show normal maternal care but altered emotionality: Potential influence of the brain corticotropin-releasing factor system.
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DOI：
10.1016/j.bbr.2017.12.034
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发表时间：
2018-04-02
影响因子：
2.7
通讯作者：
Young LJ
中科院分区：
文献类型：
--
作者：
Bosch OJ;Pohl TT;Neumann ID;Young LJ
当父亲离开家庭时，母亲患抑郁症和焦虑症的风险就会增加。在双亲、社会性一夫一妻制的草原田鼠（Microtus ochrogaster）中，突然的联系破坏会增加被动的压力应对能力，表明出现类似抑郁的行为，并且对雄性和雌性来说都是慢性压力源。然而，分离对哺乳期草原田鼠母亲的后果尚不清楚。在本研究中，共养 18 天后，一半的草原田鼠对通过移走雄性而被分开。在哺乳早期，产妇护理不受分居的影响，而分居母亲的焦虑相关行为和被动压力应对显着升高。在基础条件下，分离显着增加了下丘脑室旁核中促肾上腺皮质激素释放因子（CRF）mRNA的表达，与急性暴露于强迫游泳压力后配对雌性的水平相似。在行为测试之前，对第二组哺乳期草原田鼠进行脑室内注射媒介物或 CRF 受体拮抗剂 D-Phe。在急性输注期间的短暂限制显着减少了媒介物处理的配对组和分离组中的拱背护理，而在 D-Phe 处理的分离组中，行为没有受到损害。此外，在后者中，与焦虑相关的行为和被动压力应对正常化至与接受媒介治疗的配对母亲相似的水平。总之，母亲的投资足够强大，足以承受失去伴侣的影响，而母亲的情绪会受到影响，这可能（至少部分）是由 CRF 依赖机制介导的。该动物模型具有对单身母亲失去伴侣的行为和生理后果进行机制研究的潜力。
When fathers leave the family, mothers are at increased risk of developing depression and anxiety disorders. In biparental, socially monogamous prairie voles (Microtus ochrogaster), sudden bond disruption increases passive stress-coping, indicative of depressive-like behavior, and acts as chronic stressor in both males and females. However, the consequences of separation in lactating prairie vole mothers are unknown. In the present study, following 18 days of cohousing, half of the prairie vole pairs were separated by removing the male. In early lactation, maternal care was unaffected by separation, whereas anxiety-related behavior and passive stress-coping were significantly elevated in separated mothers. Separation significantly increased corticotropin-releasing factor (CRF) mRNA expression in the paraventricular nucleus of the hypothalamus under basal conditions, similar to levels of paired females after acute exposure to forced swim stress. A second cohort of lactating prairie voles was infused intracerebroventricularly with either vehicle or the CRF receptor antagonist D-Phe just prior to behavioral testing. The brief restraining during acute infusion significantly decreased arched back nursing in vehicle-treated paired and separated groups, whereas in the D-Phe-treated separated group the behavior was not impaired. Furthermore, in the latter, anxiety-related behavior and passive stress-coping were normalized to levels similar to vehicle-treated paired mothers. In conclusion, maternal investment is robust enough to withstand loss of the partner, whereas the mother’s emotionality is affected, which may be - at least partly - mediated by a CRF-dependent mechanism. This animal model has potential for mechanistic studies of behavioral and physiological consequences of partner loss in single mothers.
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影响因子：
3
作者：
CARTER, CS;GETZ, LL
通讯作者：
GETZ, LL
影响因子：
5
作者：
BERKMAN, PL
通讯作者：
BERKMAN, PL
影响因子：
3.7
作者：
Bosch OJ;Dabrowska J;Modi ME;Johnson ZV;Keebaugh AC;Barrett CE;Ahern TH;Guo J;Grinevich V;Rainnie DG;Neumann ID;Young LJ
通讯作者：
Young LJ
影响因子：
4.4
作者：
Afifi, TO;Cox, BJ;Enns, MW
通讯作者：
Enns, MW
影响因子：
2.9
作者：
INSEL, TR;PRESTON, S;WINSLOW, JT
通讯作者：
WINSLOW, JT