Bone-Derived Factors as Potential Biomarkers for Parkinson's Disease.
Bone-Derived Factors as Potential Biomarkers for Parkinson's Disease.
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骨源性因子作为帕金森病的潜在生物标志物
DOI：
10.3389/fnagi.2021.634213
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发表时间：
2021
影响因子：
4.8
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Lin Y;Zhou M;Dai W;Guo W;Qiu J;Zhang Z;Mo M;Ding L;Ye P;Wu Y;Zhu X;Wu Z;Xu P;Chen X
背景：帕金森病（PD）和骨质疏松症都是常见的老年性疾病。有研究表明PD与骨质疏松关系密切，骨分泌蛋白可能参与疾病的进展。目的：目的检测PD患者血浆和脑脊液（CSF）中骨源性因子（BDF）水平，并探讨其与C反应蛋白（CRP）水平、运动功能障碍及Hoehn-Yahr（HY）分期的相关性。方法：我们纳入了250例PD患者和250例对照。采用定制的蛋白抗体芯片检测血浆和脑脊液中骨钙素（OCN）、骨桥蛋白（OPN）、骨保护素（OPG）、硬化蛋白（SO）、骨形态发生蛋白2（BMP 2）和Dickkopf-1（DKK-1）的水平。采用Mann-Whitney U检验和斯皮尔曼NF-κ受体激活因子B（RANK）相关性分析数据。结果：PD患者血浆OCN、OPN水平与CRP水平、HY分期及运动功能障碍相关。此外，CSF检测的血浆评估可增强其对PD的潜在预测。结论：OCN和OPN可作为PD的潜在生物标志物。炎症反应可能参与了这两种因子与PD之间的相互作用。
Background: Parkinson’s disease (PD) and osteoporosis are both common aging diseases. It is reported that PD has a close relationship with osteoporosis and bone secretory proteins may be involved in disease progression. Objectives: To detect the bone-derived factors in plasma and cerebrospinal fluid (CSF) of patients with PD and evaluate their correlations with C-reaction protein (CRP) level, motor impairment, and Hoehn-Yahr (HY) stage of the disease. Methods: We included 250 PD patients and 250 controls. Levels of osteocalcin (OCN), osteopontin (OPN), osteoprotegerin (OPG), Sclerostin (SO), Bone morphogenetic protein 2 (BMP2), and Dickkopf-1 (DKK-1) in plasma and CSF were measured by custom protein antibody arrays. Data were analyzed using Mann–Whitney U-test and Spearman’s receptor activator of NF-κB (RANK) correlation. Results: Plasma levels of OCN and OPN were correlated with CRP levels and HY stage and motor impairment of PD. Furthermore, the plasma assessment with CSF detection may enhance their potential prediction on PD. Conclusions: OCN and OPN may serve as potential biomarkers for PD. The inflammation response may be involved in the cross-talk between the two factors and PD.
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影响因子：
7.3
作者：
Walsh MC;Choi Y
通讯作者：
Choi Y
骨钙素通过 AKT/GSK3β 信号传导改善 6-羟基多巴胺诱导的帕金森病大鼠模型中的运动功能障碍
影响因子：
4.8
作者：
Guo XZ;Shan C;Hou YF;Zhu G;Tao B;Sun LH;Zhao HY;Ning G;Li ST;Liu JM
通讯作者：
Liu JM
DOI：
10.1055/s-0034-1368709
发表时间：
2014-05
期刊：
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
影响因子：
--
作者：
Hill HS;Grams J;Walton RG;Liu J;Moellering DR;Garvey WT
通讯作者：
Garvey WT
影响因子：
11
作者：
Garcia-Olivares J;Baust T;Harris S;Hamilton P;Galli A;Amara SG;Torres GE
通讯作者：
Torres GE
影响因子：
6.1
作者：
Maetzler, Walter;Berg, Daniela;Nitsch, Cordula
通讯作者：
Nitsch, Cordula