Vitamin D supplementation of breastfed infants: a randomized dose-response trial.
Vitamin D supplementation of breastfed infants: a randomized dose-response trial.
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DOI：
10.1038/pr.2014.76
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发表时间：
2014-08
影响因子：
3.6
通讯作者：
Jeter JM
中科院分区：
文献类型：
--
作者：
Ziegler EE;Nelson SE;Jeter JM
母乳喂养的婴儿需要补充维生素D，但对必要的剂量知之甚少。这项双盲试验评估了四种不同剂量的维生素D。纯母乳喂养的婴儿（N=213）在1个月时被随机分配到4种剂量中的一种，他们在9个月内接受这些剂量，而不接受配方奶粉。这些补充剂每天提供200 IU、400 IU、600 IU或800 IU的维生素D。主要终点是血浆25（OH）D水平，次要终点是血浆PTH和钙以及疾病发生率。该研究在41° N的冬季进行。大多数婴儿在1个月时25（OH）D水平较低（<50 nmol/L），但补充水平上升。总的来说，25（OH）D的水平与维生素D剂量成正比。维生素D对疾病发生率或生长没有影响。低水平是常见的，7.8%的水平<50 nmol/L，15名婴儿有2至4个低水平。4种剂量的维生素D产生不同的血浆25（OH）D水平。较高剂量在维持母乳喂养婴儿维生素D充足方面更有效。研究结果支持400 IU/d的推荐剂量，并强调需要在出生时开始补充。
Breastfed infants require supplementation with vitamin D but little is known about the necessary dose. This double blind trial evaluated four different doses of vitamin D. Exclusively breastfed infants (N=213) were randomized at 1 month to one of 4 doses, which they received through 9 months while receiving no formula. The supplements provided daily 200 IU, 400 IU, 600 IU or 800 IU of vitamin D. The primary endpoint was plasma 25(OH)D level and secondary outcomes were plasma PTH and calcium, and illness incidence. The study was conducted during winter at 41° N. Most infants had low (<50 nmol/L) 25(OH)D levels at 1 month, but with supplementation levels rose. Overall, levels of 25(OH)D differed significantly in proportion to vitamin D dose. There were no effects of vitamin D on illness incidence or growth. Low levels were common, with 7.8% of levels being <50 nmol/L and 15 infants having 2 to 4 low levels. The 4 doses of vitamin D produced different plasma levels of 25(OH)D. The higher doses were somewhat more efficacious in maintaining vitamin D sufficiency in breastfed infants. The findings support the recommended dose of 400 IU/d and stress the need to start supplementation at birth.
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影响因子：
168.9
作者：
Wang, Thomas J.;Zhang, Feng;Richards, J. Brent;Kestenbaum, Bryan;van Meurs, Joyce B.;Berry, Diane;Kiel, Douglas P.;Streeten, Elizabeth A.;Ohlsson, Claes;Koller, Daniel L.;Peltonen, Leena;Cooper, Jason D.;O'Reilly, Paul F.;Houston, Denise K.;Glazer, Nicole L.;Vandenput, Liesbeth;Peacock, Munro;Shi, Julia;Rivadeneira, Fernando;McCarthy, Mark I.;Anneli, Pouta;de Boer, Ian H.;Mangino, Massimo;Kato, Bernet;Smyth, Deborah J.;Booth, Sarah L.;Jacques, Paul F.;Burke, Greg L.;Goodarzi, Mark;Cheung, Ching-Lung;Wolf, Myles;Rice, Kenneth;Goltzman, David;Hidiroglou, Nick;Ladouceur, Martin;Wareham, Nicholas J.;Hocking, Lynne J.;Hart, Deborah;Arden, Nigel K.;Cooper, Cyrus;Malik, Suneil;Fraser, William D.;Hartikainen, Anna-Liisa;Zhai, Guangju;Macdonald, Helen M.;Forouhi, Nita G.;Loos, Ruth J. F.;Reid, David M.;Hakim, Alan;Dennison, Elaine;Liu, Yongmei;Power, Chris;Stevens, Helen E.;Jaana, Laitinen;Vasan, Ramachandran S.;Soranzo, Nicole;Bojunga, Joerg;Psaty, Bruce M.;Lorentzon, Mattias;Foroud, Tatiana;Harris, Tamara B.;Hofman, Albert;Jonsson, John-Olov;Cauley, Jane A.;Uitterlinden, Andre G.;Gibson, Quince;Jarvelin, Marjo-Riitta;Karasik, David;Siscovick, David S.;Econs, Michael J.;Kritchevsky, Stephen B.;Florez, Jose C.;Todd, John A.;Dupuis, Josee;Hyppoenen, Elina;Spector, Timothy D.
通讯作者：
Spector, Timothy D.
影响因子：
7.1
作者：
ALAHOUHALA, M;KOSKINEN, T;VISAKORPI, JK
通讯作者：
VISAKORPI, JK
影响因子：
7.1
作者：
Novakovic, Boris;Galati, John C.;Saffery, Richard
通讯作者：
Saffery, Richard
影响因子：
5.8
作者：
HOLLIS, BW;PITTARD, WB;REINHARDT, TA
通讯作者：
REINHARDT, TA
影响因子：
120.7
作者：
Gallo, Sina;Comeau, Kathryn;Weiler, Hope
通讯作者：
Weiler, Hope