Association of Frailty, Age, and Biological Sex With Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccine-Induced Immunity in Older Adults.
Association of Frailty, Age, and Biological Sex With Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccine-Induced Immunity in Older Adults.
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DOI：
10.1093/cid/ciac397
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发表时间：
2022-08-15
期刊：
影响因子：
--
通讯作者：
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文献类型：
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男性和老年是2019年严重冠状病毒病的风险因素，但性别和年龄对严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）疫苗抗体反应的交叉作用尚未得到表征。在3剂SARS-CoV-2 mRNA疫苗接种之前和之后从老年人（年龄75-98岁）收集血浆样品，并且在第2剂之后从年轻人（年龄18-74岁）收集血浆样品，用于比较。针对疫苗病毒和相关的α、δ和Omicron变体（VOC），测量了与SARS-CoV-2抗原（刺突蛋白[S]、S受体结合结构域和核衣壳）的抗体结合、对S的功能活性和活病毒中和。疫苗接种诱导更大的抗体滴度在老年女性比老年男性，与年龄和虚弱与减少抗体反应的男性，但不是女性。在第二次给药后的6个月内，反应显著下降。第三剂恢复了功能性抗体反应，消除了老年人因性别、年龄和虚弱而造成的差异。相对于疫苗病毒，对VOC，特别是Omicron变体的反应显著降低，老年男性对VOC的滴度低于老年女性。老年人对疫苗和VOC病毒的反应低于年轻人，男性比女性差异更大。由于在接种第三剂疫苗之前抗体反应较低，年老体弱的男性可能更容易出现突破性感染。促进老年人，特别是男性的第三剂接种率，对于保护这一脆弱群体至关重要。严重急性呼吸综合征冠状病毒2信使RNA疫苗接种诱导老年女性比老年男性更大的抗体反应。年龄和虚弱只会降低男性的反应。这些影响通过第三剂疫苗消除，突出了第三剂疫苗覆盖率的必要性，特别是在老年男性中。
Male sex and old age are risk factors for severe coronavirus disease 2019, but the intersection of sex and aging on antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has not been characterized. Plasma samples were collected from older adults (aged 75–98 years) before and after 3 doses of SARS-CoV-2 mRNA vaccination, and from younger adults (aged 18–74 years) post-dose 2, for comparison. Antibody binding to SARS-CoV-2 antigens (spike protein [S], S receptor-binding domain, and nucleocapsid), functional activity against S, and live-virus neutralization were measured against the vaccine virus and the Alpha, Delta, and Omicron variants of concern (VOCs). Vaccination induced greater antibody titers in older females than in older males, with both age and frailty associated with reduced antibody responses in males but not females. Responses declined significantly in the 6 months after the second dose. The third dose restored functional antibody responses and eliminated disparities caused by sex, age, and frailty in older adults. Responses to the VOCs, particularly the Omicron variant, were significantly reduced relative to the vaccine virus, with older males having lower titers to the VOCs than older females. Older adults had lower responses to the vaccine and VOC viruses than younger adults, with greater disparities in males than in females. Older and frail males may be more vulnerable to breakthrough infections owing to low antibody responses before receipt of a third vaccine dose. Promoting third dose coverage in older adults, especially males, is crucial to protecting this vulnerable population. Severe acute respiratory syndrome coronavirus 2 messenger RNA vaccination induces greater antibody response in older females than in older males. Age and frailty reduce responses only in males. These effects are eliminated by a third vaccine dose, highlighting the need for third dose coverage, especially in older males.
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影响因子：
3.7
作者：
Chan CEZ;Seah SGK;Chye H;Massey S;Torres M;Lim APC;Wong SKK;Neo JJY;Wong PS;Lim JH;Loh GSL;Wang D;Boyd-Kirkup JD;Guan S;Thakkar D;Teo GH;Purushotorman K;Hutchinson PE;Young BE;Low JG;MacAry PA;Hentze H;Prativadibhayankara VS;Ethirajulu K;Comer JE;Tseng CK;Barrett ADT;Ingram PJ;Brasel T;Hanson BJ
通讯作者：
Hanson BJ
DOI：
10.1093/cid/ciab447
发表时间：
2021-12-06
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Canaday DH;Carias L;Oyebanji OA;Keresztesy D;Wilk D;Payne M;Aung H;St Denis K;Lam EC;Rowley CF;Berry SD;Cameron CM;Cameron MJ;Wilson B;Balazs AB;Gravenstein S;King CL
通讯作者：
King CL
DOI：
10.1016/s1473-3099(21)00460-6
发表时间：
2022-01
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Antonelli M;Penfold RS;Merino J;Sudre CH;Molteni E;Berry S;Canas LS;Graham MS;Klaser K;Modat M;Murray B;Kerfoot E;Chen L;Deng J;Österdahl MF;Cheetham NJ;Drew DA;Nguyen LH;Pujol JC;Hu C;Selvachandran S;Polidori L;May A;Wolf J;Chan AT;Hammers A;Duncan EL;Spector TD;Ourselin S;Steves CJ
通讯作者：
Steves CJ
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
64.8
作者：
Collier DA;Ferreira IATM;Kotagiri P;Datir RP;Lim EY;Touizer E;Meng B;Abdullahi A;CITIID-NIHR BioResource COVID-19 Collaboration;Elmer A;Kingston N;Graves B;Le Gresley E;Caputo D;Bergamaschi L;Smith KGC;Bradley JR;Ceron-Gutierrez L;Cortes-Acevedo P;Barcenas-Morales G;Linterman MA;McCoy LE;Davis C;Thomson E;Lyons PA;McKinney E;Doffinger R;Wills M;Gupta RK
通讯作者：
Gupta RK