Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2.
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2.
复制标题
DOI：
10.1038/s41586-021-03739-1
复制
发表时间：
2021-08
期刊：
影响因子：
64.8
通讯作者：
Gupta RK
中科院分区：
文献类型：
--
作者：
Collier DA;Ferreira IATM;Kotagiri P;Datir RP;Lim EY;Touizer E;Meng B;Abdullahi A;CITIID-NIHR BioResource COVID-19 Collaboration;Elmer A;Kingston N;Graves B;Le Gresley E;Caputo D;Bergamaschi L;Smith KGC;Bradley JR;Ceron-Gutierrez L;Cortes-Acevedo P;Barcenas-Morales G;Linterman MA;McCoy LE;Davis C;Thomson E;Lyons PA;McKinney E;Doffinger R;Wills M;Gupta RK
尽管两剂mRNA疫苗接种对SARS-CoV-2具有良好的保护作用，但关于疫苗对80岁以上人群中关注变体（VOC）的效力的信息很少。在这里，我们分析了老年参与者和年轻医护人员接种BNT162b2 mRNA疫苗后的免疫反应。第一次接种疫苗后，老年人的血清中和和结合IgG或IgA水平较低，80岁以上的参与者明显下降。80岁以上参与者的血清对B.1.1.7 （α）、B.1.351 （β）和P.1的中和能力较低。（γ）挥发性有机化合物比抵抗野生型病毒更有效，而且在第一次注射后更有可能对挥发性有机化合物缺乏任何中和作用。然而，在第二次剂量后，无论年龄大小，都可以检测到对VOC的中和作用。首次给药后，老年应答者（其血清显示中和活性）出现SARS-CoV-2尖峰特异性记忆B细胞的频率高于无应答者。老年参与者的类别转换细胞的体细胞超突变明显减少。在老年参与者中，SARS-CoV-2尖峰特异性T细胞产生的干扰素-γ和白细胞介素-2较低，这两种细胞因子主要由CD4 T细胞分泌。我们的结论是，老年人是一个高危人群，有必要采取具体措施来提高这一人群的疫苗反应，特别是在关注的变体正在传播的情况下。80岁以上的个体在第一次接种BNT162b2 mRNA疫苗后不太可能对SARS-CoV-2产生良好的免疫反应（通过中和效价测量），但在第二次接种后实现良好的中和。
Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is little information about vaccine efficacy against variants of concern (VOC) in individuals above eighty years of age. Here we analysed immune responses following vaccination with the BNT162b2 mRNA vaccine in elderly participants and younger healthcare workers. Serum neutralization and levels of binding IgG or IgA after the first vaccine dose were lower in older individuals, with a marked drop in participants over eighty years old. Sera from participants above eighty showed lower neutralization potency against the B.1.1.7 (Alpha), B.1.351 (Beta) and P.1. (Gamma) VOC than against the wild-type virus and were more likely to lack any neutralization against VOC following the first dose. However, following the second dose, neutralization against VOC was detectable regardless of age. The frequency of SARS-CoV-2 spike-specific memory B cells was higher in elderly responders (whose serum showed neutralization activity) than in non-responders after the first dose. Elderly participants showed a clear reduction in somatic hypermutation of class-switched cells. The production of interferon-γ and interleukin-2 by SARS-CoV-2 spike-specific T cells was lower in older participants, and both cytokines were secreted primarily by CD4 T cells. We conclude that the elderly are a high-risk population and that specific measures to boost vaccine responses in this population are warranted, particularly where variants of concern are circulating. Individuals over eighty years of age are less likely to mount a good immune response against SARS-CoV-2 (measured by neutralization titres) after the first dose of the BNT162b2 mRNA vaccine, but achieve good neutralization after the second dose.
登录
查看更多内容
BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
影响因子：
15.3
作者：
Schmidt, Fabian;Weisblum, Yiska;Bieniasz, Paul D.
通讯作者：
Bieniasz, Paul D.
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
DOI：
10.1056/nejmoa2102214
发表时间：
2021-05-20
期刊：
The New England journal of medicine
影响因子：
--
作者：
Madhi SA;Baillie V;Cutland CL;Voysey M;Koen AL;Fairlie L;Padayachee SD;Dheda K;Barnabas SL;Bhorat QE;Briner C;Kwatra G;Ahmed K;Aley P;Bhikha S;Bhiman JN;Bhorat AE;du Plessis J;Esmail A;Groenewald M;Horne E;Hwa SH;Jose A;Lambe T;Laubscher M;Malahleha M;Masenya M;Masilela M;McKenzie S;Molapo K;Moultrie A;Oelofse S;Patel F;Pillay S;Rhead S;Rodel H;Rossouw L;Taoushanis C;Tegally H;Thombrayil A;van Eck S;Wibmer CK;Durham NM;Kelly EJ;Villafana TL;Gilbert S;Pollard AJ;de Oliveira T;Moore PL;Sigal A;Izu A;NGS-SA Group;Wits-VIDA COVID Group
通讯作者：
Wits-VIDA COVID Group
DOI：
10.1016/j.clim.2018.04.002
发表时间：
2018-11
期刊：
Clinical immunology (Orlando, Fla.)
影响因子：
--
作者：
Ray D;Yung R
通讯作者：
Yung R