Pretreatment C-reactive protein is a predictor for outcomes after reduced-intensity allogeneic hematopoietic cell transplantation.
Pretreatment C-reactive protein is a predictor for outcomes after reduced-intensity allogeneic hematopoietic cell transplantation.
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DOI：
10.1016/j.bbmt.2008.08.004
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发表时间：
2008-11
影响因子：
4.3
通讯作者：
van Besien, Koen
中科院分区：
文献类型：
--
作者：
Artz, Andrew S.;Wickrema, Amittha;Dinner, Shira;Godley, Lucy A.;Kocherginsky, Masha;Odenike, Olatoyosi;Rich, Elizabeth S.;Stock, Wendy;Ulaszek, Jodie;Larson, Richard A.;van Besien, Koen
我们测试了两种常用的生物标记物C-反应蛋白(CRP)和白介素6(IL-6)对异基因造血细胞移植(HCT)结果的独立预后影响。对连续接受氟达拉滨、马法兰和阿伦图珠单抗统一降低强度方案的患者进行评估。分别检测81例和79例患者在预适应前提取的冻存血清中的CRP和IL-6水平。CRP值在18.5 mg/L中位数以上的患者有更多的3~4级肝毒性(P=0.08)，更长的HCT住院时间(P=0.005)，更多的aGVHD(P=0.003)，更高的无复发死亡率(P=0.01)和较差的总生存率(P=0.02)。基线C反应蛋白升高也与3~4级感染毒性增加相关(P=0.09)。相比之下，HCT前IL-6水平高于78.3 pg/ml的中位数，并没有统计学上显著增加毒性或死亡的风险。升高的造血细胞移植共病指数(HCT-CI)不能预测HCT发病率的任何指标。在调整了疾病状态、合并症、表现状态和年龄后，升高的CRP浓度仍然预示着NRM。C反应蛋白有望成为一种现成的血清生物标记物，可在HCT预适应之前进行测量，以加强对移植耐受的评估。
We tested the independent prognostic impact of two commonly used biomarkers, C-reactive protein (CRP) and interleukin-6 (IL-6), on allogeneic hematopoietic cell transplantation (HCT) outcomes. Consecutive patients who underwent a uniform reduced intensity regimen of fludarabine, melphalan and alemtuzumab were evaluated. Cryopreserved sera drawn before conditioning was available to measure CRP and IL-6 levels from 81 and 79 patients, respectively. Patients having CRP values above the median of 18.5 mg/L had significantly more grade 3 to 4 hepatic toxicity (P = 0.08), longer HCT hospital stay (P = 0.005), more aGVHD (P = 0.003), greater non-relapse mortality (NRM) (P =0.01) and inferior overall survival (P =0.02). Higher baseline CRP also correlated with more grade 3 to 4 infectious toxicity (P = 0.09). In contrast, pre-HCT IL-6 levels above the median of 78.3 pg/mL, did not confer a statistically significant increased risk of toxicities or mortality. Elevated hematopoietic cell transplantation-comorbidity index (HCT-CI) did not predict for any measure of HCT morbidity. After adjustment for disease status, comorbidity, performance status and age, elevated CRP concentration remained predictive of NRM. CRP holds promise as a readily available serum biomarker that can be measured prior to HCT conditioning to enhance estimates of transplantation tolerance.
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影响因子：
5.9
作者：
Harris, TB;Ferrucci, L;Wallace, R
通讯作者：
Wallace, R
影响因子：
20.3
作者：
Alyea, EP;Kim, HT;Soiffer, RJ
通讯作者：
Soiffer, RJ
DOI：
10.1093/gerona/61.4.380
发表时间：
2006-04-01
影响因子：
5.1
作者：
Kuo, HK;Bean, JF;Leveille, SG
通讯作者：
Leveille, SG
影响因子：
20.3
作者：
Diaconescu, R;Flowers, CR;Storb, R
通讯作者：
Storb, R
DOI：
10.1111/j.1749-6632.1982.tb22153.x
发表时间：
1982-01-01
影响因子：
5.2
作者：
MORLEY, JJ;KUSHNER, I
通讯作者：
KUSHNER, I