The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma-Recent Findings and Review.
The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma-Recent Findings and Review.
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炎症细胞因子在结直肠癌发病中的作用——最新发现和综述。
DOI：
10.3390/biomedicines10071670
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发表时间：
2022-07-11
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
炎症过程在结肠癌的发生发展中起着重要作用。肠道细胞因子网络是组织内稳态和炎症的关键介质，但也影响疾病所有阶段的癌变。最近的研究表明，炎症在锯齿状通路中比在腺瘤-癌通路中更重要。白细胞介素2因其在结直肠癌发病机制中的潜在作用和临床试验的良好结果而备受关注。恶性转化与促肿瘤和抗肿瘤细胞因子有关。促炎因子和抗炎因子之间的协调对维持体内平衡至关重要。肿瘤微环境中的免疫细胞调节免疫敏感性，促进肿瘤逃避免疫监视。因此，阐明潜在的细胞因子途径的作用及其调节作用可能是提高肿瘤免疫治疗效果的重要一步。
The inflammatory process plays a significant role in the development of colon cancer (CRC). Intestinal cytokine networks are critical mediators of tissue homeostasis and inflammation but also impact carcinogenesis at all stages of the disease. Recent studies suggest that inflammation is of greater importance in the serrated pathway than in the adenoma-carcinoma pathway. Interleukins have gained the most attention due to their potential role in CRC pathogenesis and promising results of clinical trials. Malignant transformation is associated with the pro-tumorigenic and anti-tumorigenic cytokines. The harmony between proinflammatory and anti-inflammatory factors is crucial to maintaining homeostasis. Immune cells in the tumor microenvironment modulate immune sensitivity and facilitate cancer escape from immune surveillance. Therefore, clarifying the role of underlying cytokine pathways and the effects of their modulation may be an important step to improve the effectiveness of cancer immunotherapy.
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影响因子：
64.5
作者：
Chen B;Scurrah CR;McKinley ET;Simmons AJ;Ramirez-Solano MA;Zhu X;Markham NO;Heiser CN;Vega PN;Rolong A;Kim H;Sheng Q;Drewes JL;Zhou Y;Southard-Smith AN;Xu Y;Ro J;Jones AL;Revetta F;Berry LD;Niitsu H;Islam M;Pelka K;Hofree M;Chen JH;Sarkizova S;Ng K;Giannakis M;Boland GM;Aguirre AJ;Anderson AC;Rozenblatt-Rosen O;Regev A;Hacohen N;Kawasaki K;Sato T;Goettel JA;Grady WM;Zheng W;Washington MK;Cai Q;Sears CL;Goldenring JR;Franklin JL;Su T;Huh WJ;Vandekar S;Roland JT;Liu Q;Coffey RJ;Shrubsole MJ;Lau KS
通讯作者：
Lau KS
影响因子：
8.8
作者：
Thomson A;Bento DFC;Scurr MJ;Smart K;Somerville MS;Keita ÅV;Gallimore A;Godkin A
通讯作者：
Godkin A
影响因子：
3.5
作者：
Becskei, Attila;Grusby, Michael J.
通讯作者：
Grusby, Michael J.
影响因子：
6.4
作者：
Antoniv, Taras T.;Ivashkiv, Lionel B.
通讯作者：
Ivashkiv, Lionel B.
影响因子：
5.6
作者：
Adamo, V.;Franchina, T.;Gangemi, S.
通讯作者：
Gangemi, S.